Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma
Attia ABE, Ho CJH, Chandrasekharan P, Balasundaram G, Tay HC, Burton NC, Chuang KH, Ntziachristos V, Olivo M (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 9
Pages Range: 701-708
Journal Issue: 7
Abstract
Multi-modality imaging methods are of great importance in oncologic studies for acquiring complementary information, enhancing the efficacy in tumor detection and characterization. We hereby demonstrate a hybrid non-invasive in vivo imaging approach of utilizing magnetic resonance imaging (MRI) and Multispectral Optoacoustic Tomography (MSOT) for molecular imaging of glucose uptake in an orthotopic glioblastoma in mouse. The molecular and functional information from MSOT can be overlaid on MRI anatomy via image coregistration to provide insights into probe uptake in the brain, which is verified by ex vivo fluorescence imaging and histological validation. In vivo MSOT and MRI imaging of an orthotopic glioma mouse model injected with IRDye800-2DG. Image coregistration between MSOT and MRI enables multifaceted (anatomical, functional, molecular) information from MSOT to be overlaid on MRI anatomy images to derive tumor physiological parameters such as perfusion, haemoglobin and oxygenation.
Involved external institutions
Technische Universität München (TUM)
Germany (DE)
Singapore Bioimaging Consortium (SBIC)
Singapore (SG)
iThera Medical GmbH
Germany (DE)
University of Queensland
Australia (AU)
Germany (DE)
Singapore Bioimaging Consortium (SBIC)
Singapore (SG)
iThera Medical GmbH
Germany (DE)
University of Queensland
Australia (AU)
How to cite
APA:
Attia, A.B.E., Ho, C.J.H., Chandrasekharan, P., Balasundaram, G., Tay, H.C., Burton, N.C.,... Olivo, M. (2016). Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma. Journal of Biophotonics, 9(7), 701-708. https://doi.org/10.1002/jbio.201500321
MLA:
Attia, Amalina Binte Ebrahim, et al. "Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma." Journal of Biophotonics 9.7 (2016): 701-708.
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