Hybrid multispectral optoacoustic and ultrasound tomography for morphological and physiological brain imaging

Olefir I, Mercep E, Burton NC, Ovsepian SV, Ntziachristos V (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Journal of Biomedical Optics Society of Photo-optical Instrumentation Engineers (SPIE)

Book Volume: 21

Article Number: 086005

Journal Issue: 8

DOI: 10.1117/1.JBO.21.8.086005

Abstract

Expanding usage of small animal models in biomedical research necessitates development of technologies for structural, functional, or molecular imaging that can be readily integrated in the biological laboratory. Herein, we consider dual multispectral optoacoustic (OA) and ultrasound tomography based on curved ultrasound detector arrays and describe the performance achieved for hybrid morphological and physiological brain imaging of mice in vivo. We showcase coregistered hemodynamic parameters resolved by OA tomography under baseline conditions and during alterations of blood oxygen saturation. As an internal reference, we provide imaging of abdominal organs. We illustrate the performance advantages of hybrid curved detector ultrasound and OA tomography and discuss immediate and long-term implications of our findings in the context of animal and human studies.

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) iThera Medical GmbH DE Germany (DE)

How to cite

APA:

Olefir, I., Mercep, E., Burton, N.C., Ovsepian, S.V., & Ntziachristos, V. (2016). Hybrid multispectral optoacoustic and ultrasound tomography for morphological and physiological brain imaging. Journal of Biomedical Optics, 21(8). https://doi.org/10.1117/1.JBO.21.8.086005

MLA:

Olefir, Ivan, et al. "Hybrid multispectral optoacoustic and ultrasound tomography for morphological and physiological brain imaging." Journal of Biomedical Optics 21.8 (2016).

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