Near-infrared photoacoustic imaging probe responsive to calcium

Mishra A, Jiang Y, Roberts S, Ntziachristos V, Westmeyer GG (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Analytical Chemistry American Chemical Society

Book Volume: 88

Pages Range: 10785-10789

Journal Issue: 22

DOI: 10.1021/acs.analchem.6b03039

Abstract

Photoacoustic imaging (PAI) is an attractive imaging modality that can volumetrically map the distribution of photoabsorbing molecules with deeper tissue penetration than multiphoton microscopy. To enable dynamic sensing of divalent cations via PAI, we have engineered a new reversible near-infrared probe that is more sensitive to calcium as compared to other biologically relevant cations. The metallochromic compound showed a strong reduction of its peak absorbance at 765 nm upon addition of calcium ions that was translated into robust signal changes in photoacoustic images. Therefore, the heptamethine cyanine dye will be an attractive scaffold to create a series of metallochromic sensors for molecular PAI.

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE)

How to cite

APA:

Mishra, A., Jiang, Y., Roberts, S., Ntziachristos, V., & Westmeyer, G.G. (2016). Near-infrared photoacoustic imaging probe responsive to calcium. Analytical Chemistry, 88(22), 10785-10789. https://doi.org/10.1021/acs.analchem.6b03039

MLA:

Mishra, Anurag, et al. "Near-infrared photoacoustic imaging probe responsive to calcium." Analytical Chemistry 88.22 (2016): 10785-10789.

BibTeX: Download