Statistical Molecular Target Detection Framework for Multispectral Optoacoustic Tomography

Tzoumas S, Kravtsiv A, Gao Y, Buehler A, Ntziachristos V (2016)

Publication Type: Journal article

Publication year: 2016

Journal

IEEE Transactions on Medical Imaging Institute of Electrical and Electronics Engineers (IEEE)

Book Volume: 35

Pages Range: 2534-2545

Article Number: 7497490

Journal Issue: 12

DOI: 10.1109/TMI.2016.2583791

Abstract

Statistical sub-pixel detection via the adaptive matched filter (AMF) has been shown to improve the molecular imaging sensitivity and specificity of optoacoustic (photoacoustic) imaging. Applied to multispectral optoacoustic tomography (MSOT), AMF assumes that the spatially-varying tissue spectra follow a multivariate Gaussian distribution, that the spectrum of the target molecule is precisely known and that the molecular target lies in 'low probability' within the data. However, when these assumptions are violated, AMF may result in considerable performance degradation. The objective of this work is to develop a robust statistical detection framework that is appropriately suited to the characteristics of MSOT molecular imaging. Using experimental imaging data, we perform a statistical characterization of MSOT tissue images and conclude to a detector that is based on the t-distribution. More importantly, we introduce a method for estimating the covariance matrix of the background-tissue statistical distribution, which enables robust detection performance independently of the molecular target size or intensity. The performance of the statistical detection framework is assessed through simulations and experimental in vivo measurements and compared to previously used methods.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) Karlsruhe Institute of Technology (KIT) DE Germany (DE)

How to cite

APA:

Tzoumas, S., Kravtsiv, A., Gao, Y., Buehler, A., & Ntziachristos, V. (2016). Statistical Molecular Target Detection Framework for Multispectral Optoacoustic Tomography. IEEE Transactions on Medical Imaging, 35(12), 2534-2545. https://doi.org/10.1109/TMI.2016.2583791

MLA:

Tzoumas, Stratis, et al. "Statistical Molecular Target Detection Framework for Multispectral Optoacoustic Tomography." IEEE Transactions on Medical Imaging 35.12 (2016): 2534-2545.

BibTeX: Download