Poelsterl S, Conjeti S, Navab N, Katouzian A (2016)
Publication Type: Journal article
Publication year: 2016
Book Volume: 72
Pages Range: 1-11
DOI: 10.1016/j.artmed.2016.07.004
Background In clinical research, the primary interest is often the time until occurrence of an adverse event, i.e., survival analysis. Its application to electronic health records is challenging for two main reasons: (1) patient records are comprised of high-dimensional feature vectors, and (2) feature vectors are a mix of categorical and real-valued features, which implies varying statistical properties among features. To learn from high-dimensional data, researchers can choose from a wide range of methods in the fields of feature selection and feature extraction. Whereas feature selection is well studied, little work focused on utilizing feature extraction techniques for survival analysis. Results We investigate how well feature extraction methods can deal with features having varying statistical properties. In particular, we consider multiview spectral embedding algorithms, which specifically have been developed for these situations. We propose to use random survival forests to accurately determine local neighborhood relations from right censored survival data. We evaluated 10 combinations of feature extraction methods and 6 survival models with and without intrinsic feature selection in the context of survival analysis on 3 clinical datasets. Our results demonstrate that for small sample sizes – less than 500 patients – models with built-in feature selection (Cox model with ℓ
APA:
Poelsterl, S., Conjeti, S., Navab, N., & Katouzian, A. (2016). Survival analysis for high-dimensional, heterogeneous medical data: Exploring feature extraction as an alternative to feature selection. Artificial Intelligence in Medicine, 72, 1-11. https://doi.org/10.1016/j.artmed.2016.07.004
MLA:
Poelsterl, Sebastian, et al. "Survival analysis for high-dimensional, heterogeneous medical data: Exploring feature extraction as an alternative to feature selection." Artificial Intelligence in Medicine 72 (2016): 1-11.
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