Prognostic value of gamma-glutamyl transferase in patients with diabetes mellitus and coronary artery disease
Ndrepepa G, Colleran R, Luttert A, Braun S, Cassese S, Kufner S, Hieber J, Fusaro M, Laugwitz KL, Schunkert H, Kastrati A (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 49
Pages Range: 1127-1132
Journal Issue: 15
DOI: 10.1016/j.clinbiochem.2016.05.018
Abstract
Objectives The aim of the study was to investigate the association between gamma-glutamyl transferase (GGT) activity and mortality in patients with diabetes mellitus and coronary artery disease (CAD). Design and methods The study included 1448 patients with diabetes and angiography-proven CAD who underwent percutaneous coronary intervention (PCI). Baseline GGT measurements were available in all patients. The primary outcome was 3-year mortality. Results Patients were divided into 3 groups: a group consisting of patients with a GGT activity in the 1st tertile (GGT ≤ 29.4 U/L; n = 487), a group consisting of patients with a GGT activity in the 2nd tertile (GGT > 29.4–52.5 U/L; n = 479) and a group consisting of patients with GGT in the 3rd tertile (GGT > 52.5 U/L; n = 482). Overall, there were 179 deaths: 46 (11.9%), 49 (12.1%) and 84 deaths (21.4%) among patients of the 1st, 2nd and 3rd GGT tertiles, respectively (adjusted hazard ratio [HR] = 1.25, 95% confidence interval [CI] 1.05–1.49, P = 0.011). Cardiac death occurred in 101 patients: 22 (5.8%), 30 (7.2%) and 49 deaths (12.9%) among patients of the 1st, 2nd and 3rd GGT tertiles, respectively (adjusted HR = 1.23 [0.96–1.58], P = 0.104, with risk estimates calculated per standard deviation increase in the logarithmic scale of GGT). GGT improved the risk prediction of models of all-cause (P = 0.020) but not cardiac (P = 0.135) mortality (P values show the difference in C-statistics between the models without and with GGT). Conclusion In patients with diabetes and CAD treated with PCI, elevated GGT was independently associated with the risk of 3-year all-cause mortality.
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Germany (DE)How to cite
APA:
Ndrepepa, G., Colleran, R., Luttert, A., Braun, S., Cassese, S., Kufner, S.,... Kastrati, A. (2016). Prognostic value of gamma-glutamyl transferase in patients with diabetes mellitus and coronary artery disease. Clinical Biochemistry, 49(15), 1127-1132. https://dx.doi.org/10.1016/j.clinbiochem.2016.05.018
MLA:
Ndrepepa, Gjin, et al. "Prognostic value of gamma-glutamyl transferase in patients with diabetes mellitus and coronary artery disease." Clinical Biochemistry 49.15 (2016): 1127-1132.
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