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Pseudo-healthy image synthesis for white matter lesion segmentation

Bowles C, Qin C, Ledig C, Guerrero R, Gunn R, Hammers A, Sakka E, Dickie DA, Hernandez MV, Royle N, Wardlaw J, Rhodius-Meester H, Tijms B, Lemstra AW, Van Der Flier W, Barkhof F, Scheltens P, Rueckert D (2016)

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Publication Type: Conference contribution

Publication year: 2016

Journal

Publisher: Springer Verlag

Book Volume: 9968 LNCS

Pages Range: 87-96

Conference Proceedings Title: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Event location: Athens, GRC

ISBN: 9783319466293

DOI: 10.1007/978-3-319-46630-9_9

Abstract

White matter hyperintensities (WMH) seen on FLAIR images are established as a key indicator of Vascular Dementia (VD) and other pathologies.We propose a novel modality transformation technique to generate a subject-specific pathology-free synthetic FLAIR image from a T1 -weighted image. WMH are then accurately segmented by comparing this synthesized FLAIR image to the actually acquired FLAIR image. We term this method Pseudo-Healthy Image Synthesis (PHI-Syn). The method is evaluated on data from 42 stroke patients where we compare its performance to two commonly used methods from the Lesion Segmentation Toolbox. We show that the proposed method achieves superior performance for a number of metrics. Finally, we show that the features extracted from the WMH segmentations can be used to predict a Fazekas lesion score that supports the identification of VD in a dataset of 468 dementia patients. In this application the automatically calculated features perform comparably to clinically derived Fazekas scores.

Involved external institutions

How to cite

APA:

Bowles, C., Qin, C., Ledig, C., Guerrero, R., Gunn, R., Hammers, A.,... Rueckert, D. (2016). Pseudo-healthy image synthesis for white matter lesion segmentation. In Sotirios A. Tsaftaris, Ali Gooya, Alejandro F. Frangi, Jerry L. Prince (Eds.), Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (pp. 87-96). Athens, GRC: Springer Verlag.

MLA:

Bowles, Christopher, et al. "Pseudo-healthy image synthesis for white matter lesion segmentation." Proceedings of the 1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016, Athens, GRC Ed. Sotirios A. Tsaftaris, Ali Gooya, Alejandro F. Frangi, Jerry L. Prince, Springer Verlag, 2016. 87-96.

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