The human cell atlas

Regev A, Teichmann SA, Lander ES, Amt I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Elis R, Enard W, Farmer A, Fugger L, Gottgens B, Hacohen N, Haniffa M, Hemberg M, Kim S, Klenerman P, Kriegstein A, Lein ED, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijin M, Netea M, Nolan G, Pe'Er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, Van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Book Volume: 6

Article Number: e27041

DOI: 10.7554/eLife.27041

Abstract

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.

Involved external institutions

University of Oxford United Kingdom (GB) University of Cambridge United Kingdom (GB) Newcastle University United Kingdom (GB) University of California San Francisco (UCSF) United States (USA) (US) Allen Institute for Brain Science United States (USA) (US) Icahn School of Medicine at Mount Sinai United States (USA) (US) University of Groningen / Rijksuniversiteit Groningen Netherlands (NL) Memorial Sloan Kettering Cancer Center United States (USA) (US) Stanford University United States (USA) (US) New York University (NYU) United States (USA) (US) University of Texas MD Anderson Cancer Center United States (USA) (US) The European Bioinformatics Institute (EBI) United Kingdom (GB) Wellcome Trust Sanger Institute - Genome Research Limited United Kingdom (GB) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich Germany (DE) Royal Institute of Technology / Kungliga Tekniska Högskolan (KTH) Sweden (SE) Eli and Edythe L. Broad Institute of MIT and Harvard United States (USA) (US) Weizmann Institute of Science Israel (IL) Harvard University United States (USA) (US) University of Zurich / Universität Zürich (UZH) Switzerland (CH) RIKEN Center for Life Science Technologies (CLST) Japan (JP) Princess Máxima Center Netherlands (NL) École Polytechnique Fédérale de Lausanne (EPFL) Switzerland (CH) University of Pennsylvania United States (USA) (US) Ludwig-Maximilians-Universität (LMU) Germany (DE) Karolinska Institute Sweden (SE) National Institute of Biomedical Genomics (NIBMG) India (IN) University of Cape Town (UCT) South Africa (ZA) Radboud University Nijmegen Netherlands (NL) University of Edinburgh United Kingdom (GB) Netherlands Cancer Institute (NKI) Netherlands (NL) Hubrecht Institute Netherlands (NL) University of California, Berkeley United States (USA) (US) Howard Hughes Medical Institute United States (USA) (US) Ragon Institute of MGH, MIT and Harvard United States (USA) (US) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) Takara Bio Inc. United States (USA) (US) King’s College London United Kingdom (GB) California Institute of Technology (Caltech) United States (USA) (US)

How to cite

APA:

Regev, A., Teichmann, S.A., Lander, E.S., Amt, I., Benoist, C., Birney, E.,... Yosef, N. (2017). The human cell atlas. eLife, 6. https://doi.org/10.7554/eLife.27041

MLA:

Regev, Aviv, et al. "The human cell atlas." eLife 6 (2017).

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