Non-negative constrained inversion approaches for unmixing chromophores in multispectral optoacoustic tomography

Ding L, Dean-Ben XL, Burton NC, Sobol RW, Ntziachristos V, Razansky D (2017)

Publication Type: Conference contribution

Publication year: 2017

Journal

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Publisher: SPIE

Book Volume: 10064

Conference Proceedings Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Event location: San Francisco, CA, USA

ISBN: 9781510605695

DOI: 10.1117/12.2252807

Abstract

Due to modeling and experimental imperfections, multispectral optoacoustic tomography images are often afflicted with negative values, which are further amplified when propagating into the spectrally unmixed images of chromophore concentrations. Since negative values have no physical meaning, accuracy can potentially be improved by imposing non-negativity constraints on the initial reconstructions and the unmixing steps. Herein, we compare several non-negative constrained approaches with reconstruction and spectral unmixing performed separately or combined in a single inverse step. The quantitative performance and sensitivity of the different approaches in detecting small amounts of spectrally-distinct chromophores are studied in tissue-mimicking phantoms and mouse experiments.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) iThera Medical GmbH DE Germany (DE) University of Pittsburgh US United States (USA) (US)

How to cite

APA:

Ding, L., Dean-Ben, X.L., Burton, N.C., Sobol, R.W., Ntziachristos, V., & Razansky, D. (2017). Non-negative constrained inversion approaches for unmixing chromophores in multispectral optoacoustic tomography. In Alexander A. Oraevsky, Lihong V. Wang (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. San Francisco, CA, USA: SPIE.

MLA:

Ding, Lu, et al. "Non-negative constrained inversion approaches for unmixing chromophores in multispectral optoacoustic tomography." Proceedings of the Photons Plus Ultrasound: Imaging and Sensing 2017, San Francisco, CA, USA Ed. Alexander A. Oraevsky, Lihong V. Wang, SPIE, 2017.

BibTeX: Download