Sonophore labeled RGD: a targeted contrast agent for optoacoustic imaging

Haedicke K, Brand C, Omar M, Ntziachristos V, Reiner T, Grimm J (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Photoacoustics Elsevier

Book Volume: 6

Pages Range: 1-8

DOI: 10.1016/j.pacs.2017.03.001

Abstract

Optoacoustic imaging is a rapidly expanding field for the diagnosis, characterization, and treatment evaluation of cancer. However, the availability of tumor specific exogenous contrast agents is still limited. Here, we report on a small targeted contrast agent for optoacoustic imaging using a black hole quencher^® (BHQ) dye. The sonophore BHQ-1 exhibited strong, concentration-dependent, optoacoustic signals in phantoms, demonstrating its ideal suitability for optoacoustic imaging. After labeling BHQ-1 with cyclic RGD-peptide, BHQ-1-cRGD specifically bound to αvβ3-integrin expressing glioblastoma cell spheroids in vitro. The excellent optoacoustic properties of BHQ-1-cRGD could furthermore be proven in vivo. Together with this emerging imaging modality, our sonophore labeled small peptide probe offers new possibilities for non-invasive detection of molecular structures with high resolution in vivo and furthers the specificity of optoacoustic imaging. Ultimately, the discovery of tailor-made sonophores might offer new avenues for various molecular optoacoustic imaging applications, similar to what we see with fluorescence imaging.

Involved external institutions

Memorial Sloan Kettering Cancer Center

United States (USA) (US) Technische Universität München (TUM)

Germany (DE)

How to cite

APA:

Haedicke, K., Brand, C., Omar, M., Ntziachristos, V., Reiner, T., & Grimm, J. (2017). Sonophore labeled RGD: a targeted contrast agent for optoacoustic imaging. Photoacoustics, 6, 1-8. https://dx.doi.org/10.1016/j.pacs.2017.03.001

MLA:

Haedicke, Katja, et al. "Sonophore labeled RGD: a targeted contrast agent for optoacoustic imaging." Photoacoustics 6 (2017): 1-8.

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