Diot G, Metz S, Noske A, Liapis E, Schroeder B, Ovsepian SV, Meier R, Rummeny E, Ntziachristos V (2017)
Publication Type: Journal article
Publication year: 2017
Book Volume: 23
Pages Range: 6912-6922
Journal Issue: 22
DOI: 10.1158/1078-0432.CCR-16-3200
Purpose: In a pilot study, we introduce fast handheld multispectral optoacoustic tomography (MSOT) of the breast at 28 wavelengths, aiming to identify high-resolution optoacoustic (photoacoustic) patterns of breast cancer and noncancerous breast tissue. Experimental Design: We imaged 10 female patients ages 48–81 years with malignant nonspecific breast cancer or invasive lobular carcinoma. Three healthy volunteers ages 31–36 years were also imaged. Fast-MSOT was based on unique single-frame-per-pulse (SFPP) image acquisition employed to improve the accuracy of spectral differentiation over using a small number of wavelengths. Breast tissue was illuminated at the 700–970 nm spectral range over 0.56 seconds total scan time. MSOT data were guided by ultrasonography and X-ray mammography or MRI. Results: The extended spectral range allowed the computation of oxygenated hemoglobin (HBO
APA:
Diot, G., Metz, S., Noske, A., Liapis, E., Schroeder, B., Ovsepian, S.V.,... Ntziachristos, V. (2017). Multispectral Optoacoustic Tomography (MSOT) of human breast cancer. Clinical Cancer Research, 23(22), 6912-6922. https://doi.org/10.1158/1078-0432.CCR-16-3200
MLA:
Diot, Gael, et al. "Multispectral Optoacoustic Tomography (MSOT) of human breast cancer." Clinical Cancer Research 23.22 (2017): 6912-6922.
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