Pushing the Boundaries of Neuroimaging with Optoacoustics
Ovsepian SV, Olefir I, Westmeyer G, Razansky D, Ntziachristos V (2017)
Publication Type: Journal article, Review article
Publication year: 2017
Journal
Book Volume: 96
Pages Range: 966-988
Journal Issue: 5
DOI: 10.1016/j.neuron.2017.10.022
Abstract
With the central ability to visualize a variety of endogenous chromophores and biomarkers or exogenous contrast agents, optoacoustic (photoacoustic) imaging empowers new experimental capabilities for investigating brain mechanisms and functions. Here, the operational principles of optoacoustic neuroimaging are reviewed in conjunction with recent advances enabling high-resolution and real-time observation, which extend beyond the reach of optical imaging methods. Multiple implementations of optoacoustics for monitoring hemodynamics and neuro-vascular responses in the brain are showcased. The unique capabilities of optoacoustic imaging for multi-spectral cellular and molecular sensing are discussed with reference to recent application for visualizing healthy and diseased brains. Outstanding challenges in the field are considered in the context of current and future applications of optoacoustic neuroimaging for basic and translational neuroscience research. In pushing the boundaries of brain imaging, optoacoustic methods afford major insights into the neuronal mechanisms of brain functions and organization of behavior. Ovsepian et al. review the state of the art in optoacoustic (photoacoustic) neuroimaging and discuss emerging experimental capabilities and limitations. Multiple implementations at different imaging scales and resolutions are considered in the context of present-day and future studies.
Involved external institutions
Germany (DE)How to cite
APA:
Ovsepian, S.V., Olefir, I., Westmeyer, G., Razansky, D., & Ntziachristos, V. (2017). Pushing the Boundaries of Neuroimaging with Optoacoustics. Neuron, 96(5), 966-988. https://dx.doi.org/10.1016/j.neuron.2017.10.022
MLA:
Ovsepian, Saak V., et al. "Pushing the Boundaries of Neuroimaging with Optoacoustics." Neuron 96.5 (2017): 966-988.
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