Evaluation of sclerosis in Modic changes of the spine using susceptibility-weighted magnetic resonance imaging
Boeker SM, Bender YY, Adams LC, Fallenberg EM, Wagner M, Hamm B, Makowski MR (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 88
Pages Range: 148-154
DOI: 10.1016/j.ejrad.2016.12.024
Abstract
Purpose To evaluate the diagnostic performance of susceptibility-weighted magnetic resonance imaging (SWMR) for the differentiation of sclerotic and non-sclerotic Modic changes (MC) of the spine compared to computed tomography (CT) and radiographs. Materials and methods The Institutional Ethics-Review-Board approved this prospective study in advance. Written consent was obtained from all subjects. SWMR and standard T1/T2 MR of the cervical (n = 21) and/or lumbar spine (n = 34) were performed in 54 patients. 21 patients served as control. 18 patients were evaluated with CT; in all other patients radiographs were available. 67 Modic changes were identified on T1/T2 MR. On SWMR changes were classified as sclerotic and non-sclerotic based on signal intensity measurements. The sensitivity and specificity of SWMR and T1/T2 MR for differentiating between sclerotic and non-sclerotic Modic changes were determined with CT and radiographs as reference standard. Results On SWMR, signal measurements between sclerotic and non-sclerotic Modic changes differed significantly (p < 0.01). On T1- and T2-weighted MR no significant difference (p > 0.05) was measured. On SWMR, a reliable differentiation between sclerotic and non-sclerotic Modic changes could be achieved, with a sensitivity of 100% and specificity of 95%. In contrast, the combination of T1-/T2-weighted MR yielded a significantly lower sensitivity to detect sclerosis (20%). Conclusion SWMR allows a reliable detection of sclerosis in Modic changes with a higher accuracy compared to standard spine MR sequences, using radiographs and CT as reference standard.
Involved external institutions
Germany (DE)How to cite
APA:
Boeker, S.M., Bender, Y.Y., Adams, L.C., Fallenberg, E.M., Wagner, M., Hamm, B., & Makowski, M.R. (2017). Evaluation of sclerosis in Modic changes of the spine using susceptibility-weighted magnetic resonance imaging. European Journal of Radiology, 88, 148-154. https://doi.org/10.1016/j.ejrad.2016.12.024
MLA:
Boeker, Sarah M., et al. "Evaluation of sclerosis in Modic changes of the spine using susceptibility-weighted magnetic resonance imaging." European Journal of Radiology 88 (2017): 148-154.
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