Measurement of extracellular volume and transit time heterogeneity using contrast-enhanced myocardial perfusion MRI in patients after acute myocardial infarction

Kunze KP, Rischpler C, Hayes C, Ibrahim T, Laugwitz KL, Haase A, Schwaiger M, Nekolla SG (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Magnetic Resonance in Medicine Wiley

Book Volume: 77

Pages Range: 2320-2330

Journal Issue: 6

DOI: 10.1002/mrm.26320

Abstract

Purpose: To assess the ability of dynamic contrast-enhanced myocardial perfusion MRI to measure extracellular volume (ECV) and to investigate the possibility of estimating capillary transit time heterogeneity (CTH) in patients after myocardial infarction and successful revascularization. Methods: Twenty-four perfusion data sets were acquired on a 3 Tesla positron emission tomography (PET)/MRI scanner. Three perfusion models of different complexity were implemented in a hierarchical fashion with an Akaike information criterion being used to determine the number of fit parameters supported by the data. Results were compared sector-wise to ECV from an equilibrium T1 mapping method (modified look-locker inversion recovery (MOLLI)). Results: ECV derived from the perfusion analysis correlated well with equilibrium measurements (R² = 0.76). Estimation of CTH was supported in 16% of sectors (mostly remote). Inclusion of a nonzero CTH parameter usually led to lower estimates of first-pass extraction and slightly higher estimates of blood volume and flow. Estimation of the capillary permeability-surface area product was feasible in 81% of sectors. Conclusion: Transit time heterogeneity has a measurable effect on the kinetic analysis of myocardial perfusion MRI data, and Gd-DTPA extravasation in the myocardium is usually not flow-limited in infarct-related pathology. Measurement of myocardial ECV using perfusion imaging could provide a scan-time efficient alternative to methods based on T1 mapping. Magn Reson Med 77:2320–2330, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Siemens AG, Healthcare Sector DE Germany (DE) Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK e.V.) DE Germany (DE)

How to cite

APA:

Kunze, K.P., Rischpler, C., Hayes, C., Ibrahim, T., Laugwitz, K.-L., Haase, A.,... Nekolla, S.G. (2017). Measurement of extracellular volume and transit time heterogeneity using contrast-enhanced myocardial perfusion MRI in patients after acute myocardial infarction. Magnetic Resonance in Medicine, 77(6), 2320-2330. https://doi.org/10.1002/mrm.26320

MLA:

Kunze, Karl P., et al. "Measurement of extracellular volume and transit time heterogeneity using contrast-enhanced myocardial perfusion MRI in patients after acute myocardial infarction." Magnetic Resonance in Medicine 77.6 (2017): 2320-2330.

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