High-precision radiotherapy for meningiomas: Long-term results and patient-reported outcome (PRO) Hochpräzisionsstrahlentherapie bei Meningeomen: Langzeitergebnisse und patientenberichtete Endpunkte
Kessel KA, Fischer H, Oechnser M, Zimmer C, Meyer B, Combs SE (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 193
Pages Range: 921-930
Journal Issue: 11
DOI: 10.1007/s00066-017-1156-3
Abstract
Objective To evaluate long-term outcome after high-precision radiotherapy (RT) of meningioma patients in terms of survival and side effects. Methods We analyzed 275 meningioma cases: 147 lowgrade and 43 high-grade meningiomas (WHO II: n = 40, III: n = 3). In all, 85 patients had no pathologically confirmed histology but were determined as low-grade based on multimodal imaging. Surgery was performed in 183 cases. RT was delivered as either radiosurgery (RS, n = 16), fractionated stereotactic radiotherapy (FSRT, n = 241), or intensity- modulated radiation therapy (IMRT, n = 18). Of 218 patients contacted for patient-reported-outcome (PRO), 207 responded (95%). Results Median follow-up was 7.2 years. For low-grade meningioma the survival rate (OS) was 97% at 3 years, 85% at 10 years, and 64% at 15 years, for atypical meningioma 91% at 3 years, 62% at 10 years, and 50% at 15 years. Local control rate (PFS) for low-grade meningioma was 91% at 3 years, 87% at 5 years, and 86% at 10 years, for atypical cases 67% at 3 years and 55% at 5 years. Of all, 3.0% of patients reported worsened or new symptoms grade ≥3 during RT and the first 6 months thereafter; 17.5% reported a deterioration after more than 2 years. We found the prognostic factors tumor volume and age significantly influencing OS and PFS. Conclusion Complemented by PRO, we found long-term low toxicity rates in addition to excellent local control. Thus, due to the beneficial risk-benefit profile of benign and high-risk meningiomas, RT should be performed as adjuvant treatment and should not be postponed until tumor progression.
Involved external institutions
Germany (DE)How to cite
APA:
Kessel, K.A., Fischer, H., Oechnser, M., Zimmer, C., Meyer, B., & Combs, S.E. (2017). High-precision radiotherapy for meningiomas: Long-term results and patient-reported outcome (PRO) Hochpräzisionsstrahlentherapie bei Meningeomen: Langzeitergebnisse und patientenberichtete Endpunkte. Strahlentherapie und Onkologie, 193(11), 921-930. https://doi.org/10.1007/s00066-017-1156-3
MLA:
Kessel, Kerstin A., et al. "High-precision radiotherapy for meningiomas: Long-term results and patient-reported outcome (PRO) Hochpräzisionsstrahlentherapie bei Meningeomen: Langzeitergebnisse und patientenberichtete Endpunkte." Strahlentherapie und Onkologie 193.11 (2017): 921-930.
BibTeX: Download