Brain lesion segmentation through image synthesis and outlier detection
Bowles C, Qin C, Guerrero R, Gunn R, Hammers A, Dickie DA, Hernandez MV, Wardlaw J, Rueckert D (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 16
Pages Range: 643-658
DOI: 10.1016/j.nicl.2017.09.003
Abstract
Cerebral small vessel disease (SVD) can manifest in a number of ways. Many of these result in hyperintense regions visible on T2-weighted magnetic resonance (MR) images. The automatic segmentation of these lesions has been the focus of many studies. However, previous methods tended to be limited to certain types of pathology, as a consequence of either restricting the search to the white matter, or by training on an individual pathology. Here we present an unsupervised abnormality detection method which is able to detect abnormally hyperintense regions on FLAIR regardless of the underlying pathology or location. The method uses a combination of image synthesis, Gaussian mixture models and one class support vector machines, and needs only be trained on healthy tissue. We evaluate our method by comparing segmentation results from 127 subjects with SVD with three established methods and report significantly superior performance across a number of metrics.
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How to cite
APA:
Bowles, C., Qin, C., Guerrero, R., Gunn, R., Hammers, A., Dickie, D.A.,... Rueckert, D. (2017). Brain lesion segmentation through image synthesis and outlier detection. NeuroImage: Clinical, 16, 643-658. https://doi.org/10.1016/j.nicl.2017.09.003
MLA:
Bowles, Christopher, et al. "Brain lesion segmentation through image synthesis and outlier detection." NeuroImage: Clinical 16 (2017): 643-658.
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