Home Publications Research Grants Inventions & Patents Awards Additional Research Activities Faculties & Institutions Research Areas

BESNet: Boundary-enhanced segmentation of cells in histopathological images

Oda H, Roth HR, Chiba K, Sokolic J, Kitasaka T, Oda M, Hinoki A, Uchida H, Schnabel JA, Mori K (2018)

---

Publication Type: Conference contribution

Publication year: 2018

Journal

Publisher: Springer Verlag

Book Volume: 11071 LNCS

Pages Range: 228-236

Conference Proceedings Title: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Event location: Granada, ESP

ISBN: 9783030009335

DOI: 10.1007/978-3-030-00934-2_26

Abstract

We propose a novel deep learning method called Boundary-Enhanced Segmentation Network (BESNet) for the detection and semantic segmentation of cells on histopathological images. The semantic segmentation of small regions using fully convolutional networks typically suffers from inaccuracies around the boundaries of small structures, like cells, because the probabilities often become blurred. In this work, we propose a new network structure that encodes input images to feature maps similar to U-net but utilizes two decoding paths that restore the original image resolution. One decoding path enhances the boundaries of cells, which can be used to improve the quality of the entire cell segmentation achieved in the other decoding path. We explore two strategies for enhancing the boundaries of cells: (1) skip connections of feature maps, and (2) adaptive weighting of loss functions. In (1), the feature maps from the boundary decoding path are concatenated with the decoding path for entire cell segmentation. In (2), an adaptive weighting of the loss for entire cell segmentation is performed when boundaries are not enhanced strongly, because detecting such parts is difficult. The detection rate of ganglion cells was 80.0% with 1.0 false positives per histopathology slice. The mean Dice index representing segmentation accuracy was 74.0%. BESNet produced a similar detection performance and higher segmentation accuracy than comparable U-net architectures without our modifications.

Involved external institutions

How to cite

APA:

Oda, H., Roth, H.R., Chiba, K., Sokolic, J., Kitasaka, T., Oda, M.,... Mori, K. (2018). BESNet: Boundary-enhanced segmentation of cells in histopathological images. In Gabor Fichtinger, Christos Davatzikos, Carlos Alberola-López, Alejandro F. Frangi, Julia A. Schnabel (Eds.), Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (pp. 228-236). Granada, ESP: Springer Verlag.

MLA:

Oda, Hirohisa, et al. "BESNet: Boundary-enhanced segmentation of cells in histopathological images." Proceedings of the 21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018, Granada, ESP Ed. Gabor Fichtinger, Christos Davatzikos, Carlos Alberola-López, Alejandro F. Frangi, Julia A. Schnabel, Springer Verlag, 2018. 228-236.

BibTeX: Download