Kannan P, Kretzschmar WW, Winter H, Warren D, Bates R, Allen PD, Syed N, Irving B, Papiez BW, Kaeppler J, Markelc B, Kinchesh P, Gilchrist S, Smart S, Schnabel JA, Maughan T, Harris AL, Muschel RJ, Partridge M, Sharma RA, Kersemans V (2018)
Publication Type: Journal article
Publication year: 2018
Book Volume: 24
Pages Range: 4694-4704
Journal Issue: 19
DOI: 10.1158/1078-0432.CCR-18-0033
Purpose: Tumor vessels influence the growth and response of tumors to therapy. Imaging vascular changes in vivo using dynamic contrast-enhanced MRI (DCE-MRI) has shown potential to guide clinical decision making for treatment. However, quantitative MR imaging biomarkers of vascular function have not been widely adopted, partly because their relationship to structural changes in vessels remains unclear. We aimed to elucidate the relationships between vessel function and morphology in vivo. Experimental Design: Untreated preclinical tumors with different levels of vascularization were imaged sequentially using DCE-MRI and CT. Relationships between functional parameters from MR (iAUC, Ktrans, and BAT
APA:
Kannan, P., Kretzschmar, W.W., Winter, H., Warren, D., Bates, R., Allen, P.D.,... Kersemans, V. (2018). Functional parameters derived from magnetic resonance imaging reflect vascular morphology in preclinical tumors and in human liver metastases. Clinical Cancer Research, 24(19), 4694-4704. https://doi.org/10.1158/1078-0432.CCR-18-0033
MLA:
Kannan, Pavitra, et al. "Functional parameters derived from magnetic resonance imaging reflect vascular morphology in preclinical tumors and in human liver metastases." Clinical Cancer Research 24.19 (2018): 4694-4704.
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