Propagation-based phase-contrast tomography of a Guinea pig inner ear with cochlear implant using a model-based iterative reconstruction algorithm
Hehn L, Gradl R, Voss A, Guenther B, Dierolf M, Jud C, Willer K, Allner S, Hammel JU, Hessler R, Morgan KS, Herzen J, Hemmert W, Pfeiffer F (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 9
Pages Range: 5330-5339
Article Number: #337870
Journal Issue: 11
DOI: 10.1364/BOE.9.005330
Abstract
Propagation-based phase-contrast computed tomography has become a valuable tool for visualization of three-dimensional biological samples, due to its high contrast between materials with similar attenuation properties. However, one of the most-widely used phase-retrieval algorithms imposes a homogeneity assumption onto the sample, which leads to artifacts for numerous applications where this assumption is violated. Prominent examples are biological samples with highly-absorbing implants. Using synchrotron radiation, we demonstrate by the example of a guinea pig inner ear with a cochlear implant electrode, how a recently developed model-based iterative algorithm for propagation-based phase-contrast computed tomography yields distinct benefits for such a task. We find that the model-based approach improves the overall image quality, removes the detrimental influence of the implant and accurately visualizes the cochlea.
Involved external institutions
Technische Universität München (TUM)
Germany (DE)
Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH (HZG)
Germany (DE)
MED-EL (Austria)
Austria (AT)
Germany (DE)
Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH (HZG)
Germany (DE)
MED-EL (Austria)
Austria (AT)
How to cite
APA:
Hehn, L., Gradl, R., Voss, A., Guenther, B., Dierolf, M., Jud, C.,... Pfeiffer, F. (2018). Propagation-based phase-contrast tomography of a Guinea pig inner ear with cochlear implant using a model-based iterative reconstruction algorithm. Biomedical Optics Express, 9(11), 5330-5339. https://doi.org/10.1364/BOE.9.005330
MLA:
Hehn, Lorenz, et al. "Propagation-based phase-contrast tomography of a Guinea pig inner ear with cochlear implant using a model-based iterative reconstruction algorithm." Biomedical Optics Express 9.11 (2018): 5330-5339.
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