Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography

Hellbach K, Baehr A, De Marco F, Willer K, Gromann LB, Herzen J, Dmochewitz M, Auweter S, Fingerle AA, Noeel PB, Rummeny EJ, Yaroshenko A, Maack HI, Pralow T, Van Der Heijden H, Wieberneit N, Proksa R, Koehler T, Rindt K, Schroeter TJ, Mohr J, Bamberg F, Ertl-Wagner B, Pfeiffer F, Reiser MF (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 8

Article Number: 2602

Journal Issue: 1

DOI: 10.1038/s41598-018-20985-y

Abstract

The aim of this study was to assess the diagnostic value of x-ray dark-field radiography to detect pneumothoraces in a pig model. Eight pigs were imaged with an experimental grating-based large-animal dark-field scanner before and after induction of a unilateral pneumothorax. Image contrast-to-noise ratios between lung tissue and the air-filled pleural cavity were quantified for transmission and dark-field radiograms. The projected area in the object plane of the inflated lung was measured in dark-field images to quantify the collapse of lung parenchyma due to a pneumothorax. Means and standard deviations for lung sizes and signal intensities from dark-field and transmission images were tested for statistical significance using Student's two-tailed t-test for paired samples. The contrast-to-noise ratio between the air-filled pleural space of lateral pneumothoraces and lung tissue was significantly higher in the dark-field (3.65 ± 0.9) than in the transmission images (1.13 ± 1.1; p = 0.002). In case of dorsally located pneumothoraces, a significant decrease (-20.5%; p > 0.0001) in the projected area of inflated lung parenchyma was found after a pneumothorax was induced. Therefore, the detection of pneumothoraces in x-ray dark-field radiography was facilitated compared to transmission imaging in a large animal model.

Involved external institutions

Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Philips Deutschland GmbH DE Germany (DE) Karlsruhe Institute of Technology (KIT) DE Germany (DE)

How to cite

APA:

Hellbach, K., Baehr, A., De Marco, F., Willer, K., Gromann, L.B., Herzen, J.,... Reiser, M.F. (2018). Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-20985-y

MLA:

Hellbach, Katharina, et al. "Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography." Scientific Reports 8.1 (2018).

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