Nonlinear optoacoustic readings from diffusive media at near-infrared wavelengths
Malekzadeh-Najafabadi J, Prakash J, Ntziachristos V (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 11
Article Number: e201600310
Journal Issue: 1
Abstract
Optoacoustic (photoacoustic) imaging assumes that the detected signal varies linearly with laser energy. However, nonlinear intensity responses as a function of light fluence have been suggested in optoacoustic microscopy, that is, within the first millimeter of tissue. In this study, we explore the presence of nonlinearity deeper in tissue (~4 mm), as it relates to optoacoustic mesoscopy, and investigate the fluence required to delineate a switch from linear to nonlinear behavior. Optoacoustic signal nonlinearity is studied for different materials, different wavelengths and as a function of changes in the scattering and absorption coefficient of the medium imaged. We observe fluence thresholds in the mJ/cm2 range and preliminary find that different materials may exhibit different nonlinearity patterns. We discuss the implications of nonlinearity in relation to image accuracy and quantification in optoacoustic tomography.
Involved external institutions
Germany (DE)How to cite
APA:
Malekzadeh-Najafabadi, J., Prakash, J., & Ntziachristos, V. (2018). Nonlinear optoacoustic readings from diffusive media at near-infrared wavelengths. Journal of Biophotonics, 11(1). https://doi.org/10.1002/jbio.201600310
MLA:
Malekzadeh-Najafabadi, Jaber, Jaya Prakash, and Vasilis Ntziachristos. "Nonlinear optoacoustic readings from diffusive media at near-infrared wavelengths." Journal of Biophotonics 11.1 (2018).
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