A Bayesian Approach to Eigenspectra Optoacoustic Tomography

Olefir I, Tzoumas S, Yang H, Ntziachristos V (2018)

Publication Type: Journal article

Publication year: 2018

Journal

IEEE Transactions on Medical Imaging Institute of Electrical and Electronics Engineers (IEEE)

Book Volume: 37

Pages Range: 2070-2079

Article Number: 8315499

Journal Issue: 9

DOI: 10.1109/TMI.2018.2815760

Abstract

The quantification of hemoglobin oxygen saturation (sO 2 ) with multispectral optoacoustic (OA) (photoacoustic) tomography (MSOT) is a complex spectral unmixing problem, since the OA spectra of hemoglobin are modified with tissue depth due to depth (location) and wavelength dependencies of optical fluence in tissue. In a recent work, a method termed eigenspectra MSOT (eMSOT) was proposed for addressing the dependence of spectra on fluence and quantifying blood sO 2 in deep tissue. While eMSOT offers enhanced sO 2 quantification accuracy over conventional unmixing methods, its performance may be compromised by noise and image reconstruction artifacts. In this paper, we propose a novel Bayesian method to improve eMSOT performance in noisy environments. We introduce a spectral reliability map, i.e., a method that can estimate the level of noise superimposed onto the recorded OA spectra. Using this noise estimate, we formulate eMSOT as a Bayesian inverse problem where the inversion constraints are based on probabilistic graphical models. Results: based on numerical simulations indicate that the proposed method offers improved accuracy and robustness under high noise levels due the adaptive nature of the Bayesian method.

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich

Germany (DE) Stanford University

United States (USA) (US)

How to cite

APA:

Olefir, I., Tzoumas, S., Yang, H., & Ntziachristos, V. (2018). A Bayesian Approach to Eigenspectra Optoacoustic Tomography. IEEE Transactions on Medical Imaging, 37(9), 2070-2079. https://doi.org/10.1109/TMI.2018.2815760

MLA:

Olefir, Ivan, et al. "A Bayesian Approach to Eigenspectra Optoacoustic Tomography." IEEE Transactions on Medical Imaging 37.9 (2018): 2070-2079.

BibTeX: Download