Contrast-Enhanced Magnetic Resonance Angiography Using a Novel Elastin-Specific Molecular Probe in an Experimental Animal Model
Reimann C, Brangsch J, Kaufmann JO, Adams LC, Onthank DC, Robinson SP, Botnar RM, Collettini F, Makowski MR (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 2018
Article Number: 9217456
DOI: 10.1155/2018/9217456
Abstract
Objectives. The aim of this study was to test the potential of a new elastin-specific molecular agent for the performance of contrast-enhanced first-pass and 3D magnetic resonance angiography (MRA), compared to a clinically used extravascular contrast agent (gadobutrol) and based on clinical MR sequences. Materials and Methods. Eight C57BL/6J mice (BL6, male, aged 10 weeks) underwent a contrast-enhanced first-pass and 3D MR angiography (MRA) of the aorta and its main branches. All examinations were on a clinical 3 Tesla MR system (Siemens Healthcare, Erlangen, Germany). The clinical dose of 0.1 mmol/kg was administered in both probes. First, a time-resolved MRA (TWIST) was acquired during the first-pass to assess the arrival and washout of the contrast agent bolus. Subsequently, a high-resolution 3D MRA sequence (3D T1 FLASH) was acquired. Signal-to-noise ratios (SNRs) and contrast-to-noise ratios (CNRs) were calculated for all sequences. Results. The elastin-specific MR probe and the extravascular imaging agent (gadobutrol) enable high-quality MR angiograms in all animals. During the first-pass, the probes demonstrated a comparable peak enhancement (300.6 ± 32.9 vs. 288.5 ± 33.1, p>0.05). Following the bolus phase, both agents showed a comparable intravascular enhancement (SNR: 106.7 ± 11 vs. 102.3 ± 5.3; CNR 64.5 ± 7.4 vs. 61.1 ± 7.2, p>0.05). Both agents resulted in a high image quality with no statistical difference (p>0.05). Conclusion. The novel elastin-specific molecular probe enables the performance of first-pass and late 3D MR angiography with an intravascular contrast enhancement and image quality comparable to a clinically used extravascular contrast agent.
Involved external institutions
Charité - Universitätsmedizin Berlin
Germany (DE)
Lantheus Medical Imaging
United States (USA) (US)
King’s College London
United Kingdom (GB)
Germany (DE)
Lantheus Medical Imaging
United States (USA) (US)
King’s College London
United Kingdom (GB)
How to cite
APA:
Reimann, C., Brangsch, J., Kaufmann, J.O., Adams, L.C., Onthank, D.C., Robinson, S.P.,... Makowski, M.R. (2018). Contrast-Enhanced Magnetic Resonance Angiography Using a Novel Elastin-Specific Molecular Probe in an Experimental Animal Model. Contrast Media & Molecular Imaging, 2018. https://doi.org/10.1155/2018/9217456
MLA:
Reimann, Carolin, et al. "Contrast-Enhanced Magnetic Resonance Angiography Using a Novel Elastin-Specific Molecular Probe in an Experimental Animal Model." Contrast Media & Molecular Imaging 2018 (2018).
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