Randomised comparison of vascular response to biodegradable polymer sirolimus eluting and permanent polymer everolimus eluting stents: An optical coherence tomography study
Koppara T, Tada T, Xhepa E, Kutner S, Byrne RA, Ibrahim T, Laugwitz KL, Kastrati A, Joner M (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 258
Pages Range: 42-49
DOI: 10.1016/j.ijcard.2018.01.011
Abstract
Background: Drug-eluting stents with biodegradable polymer coatings have shown promising outcomes in randomised studies. Methods: We compared neointimal healing patterns including strut coverage and assessed neointimal maturity using a novel algorithm in coronary lesions treated with sirolimus-eluting stents with biodegradable polymer coating (BP-SES) or everolimus eluting stents with permanent polymer coating (PP-EES) using optical coherence tomography after 6 months. Results: A total of 39 patients were randomised to BP-SES (n = 19) or PP-EES (n = 20) for the treatment of coronary lesions. Of those, 29 patients (14 BP-SES and 15 PP-EES) underwent optical coherence tomography (OCT) and angiography at 6-month follow-up. Tissue coverage and apposition were assessed in a total of 6162 struts (BP-SES, n = 2889; PP-EES, n = 3273). Neointimal maturity was assessed in 3672 neointimal regions above struts using grey scale intensity analysis. OCT analysis showed neointimal coverage of 2433 (BP-SES) vs. 2702 (PP-EES) struts (84.2% vs. 82.6%, p = 0.70), whereas the remainder was uncovered after 6 months. Mean neointimal thickness did not differ significantly between groups (54.3 ± 7.8 μm vs. 80 ± 14.6 μm, p = 0.12). The rate of malapposed struts was comparable between groups (1.3% vs. 2.2%, p = 0.27). Grey scale signal intensity analysis showed mature tissue coverage of struts in 46.2% in BP-SES vs. 31.8% in PP-EES (p = 0.31) of neointimal regions. Conclusion: The present study showed comparable early vascular healing response characterised by neointimal coverage with mainly immature neointima in both BP-SES and PP-EES.
Involved external institutions
Technische Universität München (TUM)
Germany (DE)
Munich Heart Alliance am Institut für Pharmakologie und Toxikologie
Germany (DE)
Germany (DE)
Munich Heart Alliance am Institut für Pharmakologie und Toxikologie
Germany (DE)
How to cite
APA:
Koppara, T., Tada, T., Xhepa, E., Kutner, S., Byrne, R.A., Ibrahim, T.,... Joner, M. (2018). Randomised comparison of vascular response to biodegradable polymer sirolimus eluting and permanent polymer everolimus eluting stents: An optical coherence tomography study. International Journal of Cardiology, 258, 42-49. https://doi.org/10.1016/j.ijcard.2018.01.011
MLA:
Koppara, Tobias, et al. "Randomised comparison of vascular response to biodegradable polymer sirolimus eluting and permanent polymer everolimus eluting stents: An optical coherence tomography study." International Journal of Cardiology 258 (2018): 42-49.
BibTeX: Download