Physical activity, muscular strength, and polypharmacy among older multimorbid persons: Results from the KORA-Age study
Volaklis KA, Thorand B, Peters A, Halle M, Heier M, Strasser B, Amann U, Ladwig KH, Schulz H, Koenig W, Meisinger C (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 28
Pages Range: 604-612
Journal Issue: 2
DOI: 10.1111/sms.12884
Abstract
The purpose of this study was to examine whether physical activity (PA) and muscular strength (MS) are related to polypharmacy. Our cross-sectional analysis was based on 711 patients with multimorbidity (MMB), aged 65-94 years, who participated in the KORA-Age study. Participants underwent a face-to-face interview and extensive physical examinations including anthropometric measurements, registration of chronic diseases, determination of health-related behaviors (smoking, alcohol intake, physical activity, etc.), collection of blood samples and measurement of hand-grip strength. PPha was defined as the use of >4 drugs and MMB as having ≥2 of 13 chronic diseases. Prevalence of PPha was 44.6% (n=317), and a significant difference was found in the number of drugs used between participants with and without PPha (7.2±2.1 vs 2.5±1.2, P<.001). Patients in the lower compared to the upper tertile of physical activity had a significantly increased odds to be on PPha (OR: 1.64, 95% CI: 1.05-2.56, P=.031) after controlling for age, gender, BMI, family status, education, alcohol intake, smoking habits, number of diseases, hs-CRP, and telomere length. On the contrary, no significant association between muscular strength and PPha was found (OR: 1.04, 95% CI: 0.66-1.63, P=.873) after multivariable adjustment. Among older persons with MMB, lower levels of physical activity, but not low muscular strength, are associated with higher odds of PPha. Increasing the levels of physical activity appears to be highly recommended in order to potentially reduce the risk of PPha among multimorbid persons aged 65 and older.
Involved external institutions
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
Medizinische Universität Innsbruck
Austria (AT)
Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK e.V.)
Germany (DE)
Technische Universität München (TUM)
Germany (DE)
Germany (DE)
Medizinische Universität Innsbruck
Austria (AT)
Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK e.V.)
Germany (DE)
Technische Universität München (TUM)
Germany (DE)
How to cite
APA:
Volaklis, K.A., Thorand, B., Peters, A., Halle, M., Heier, M., Strasser, B.,... Meisinger, C. (2018). Physical activity, muscular strength, and polypharmacy among older multimorbid persons: Results from the KORA-Age study. Scandinavian journal of medicine & science in sports, 28(2), 604-612. https://doi.org/10.1111/sms.12884
MLA:
Volaklis, K. A., et al. "Physical activity, muscular strength, and polypharmacy among older multimorbid persons: Results from the KORA-Age study." Scandinavian journal of medicine & science in sports 28.2 (2018): 604-612.
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