Muscular Strength is Independently Associated with Cystatin C: The KORA-Age Study

Volaklis K, Thorand B, Peters A, Halle M, Margot H, Amann U, Ladwig KH, Schulz H, Koenig W, Meisinger C (2018)

Publication Type: Journal article

Publication year: 2018

Journal

International Journal of Sports Medicine Thieme Publishing / Georg Thieme Verlag

Book Volume: 39

Pages Range: 225-231

Journal Issue: 3

DOI: 10.1055/s-0043-123649

Abstract

The purpose of this study was to investigate if there is a link between muscular strength (MS) and markers of chronic kidney disease (CKD) among older adults. The cross-sectional analysis based on 1041 men and women, aged 65-94 years, who participated in the KORA-Age study. Participants underwent an interview and extensive examinations including anthropometric measurements, diseases and drug intake registration, determination of health-related behaviors, collection of blood samples for measurements of cystatin C and maximal muscle strength evaluation. One-Way ANOVA revealed significant differences in both mean cystatin C (1.16±0.37 vs. 1.03±0.29 vs. 0.93±0.24 mg/L, p<0.001) and mean eGFRcysC (63.61±18.61 vs. 72.14±18.92 vs. 79.87±18.19 ml/min/1.73 m 2, p<0.05) across thirds of maximal muscular strength (from lowest to highest). MS in the lowest third was significantly associated with increased odds of having elevated cystatin C (OR: 1.70, 95% CI: 1.01-2.85, p=0.043) after controlling for age, gender, fat mass, fat-free mass, alcohol intake, smoking status, number of regularly used medications, multimorbidity status, hs-CRP, telomere length and levels of physical activity. Lower levels of MS are independently associated with higher concentrations of cystatin C and lower eGFRcysC in older individuals. Increasing the levels of muscular strength may be useful to prevent the age-related CKD disease of older adults.

Involved external institutions

Klinikum rechts der Isar DE Germany (DE) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) Technische Universität Dresden DE Germany (DE) Universität Ulm DE Germany (DE)

How to cite

APA:

Volaklis, K., Thorand, B., Peters, A., Halle, M., Margot, H., Amann, U.,... Meisinger, C. (2018). Muscular Strength is Independently Associated with Cystatin C: The KORA-Age Study. International Journal of Sports Medicine, 39(3), 225-231. https://doi.org/10.1055/s-0043-123649

MLA:

Volaklis, Konstantinos, et al. "Muscular Strength is Independently Associated with Cystatin C: The KORA-Age Study." International Journal of Sports Medicine 39.3 (2018): 225-231.

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