Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction

Baldassarri F, Schwedhelm E, Atzler D, Boeger RH, Cordts K, Haller B, Pressler A, Mueller S, Suchy C, Wachter R, Duengen HD, Hasenfuss G, Pieske B, Halle M, Edelmann F, Duvinage A (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Biomarkers Informa Healthcare

Book Volume: 23

Pages Range: 540-550

Journal Issue: 6

DOI: 10.1080/1354750X.2018.1460762

Abstract

Objective: Elevated levels of arginine derivatives in the NO pathway, such as asymmetric dimethylarginine (ADMA), are related to disease severity and reduced exercise capacity in heart failure (HF). We investigated the influence of exercise intervention on these parameters and on L-arginine (L-Arg) and L-homoarginine (L-hArg) in HF with preserved ejection fraction (HFpEF) patients. Material and methods: Sixty-two patients (65 ± 6 years) were included in this analysis and randomized to supervised endurance/resistance training (ET) or to usual care (UC). EDTA-plasma was analysed for NO metabolites. Results: There were baseline associations for adjusted values of maximum workload with ADMA (r= −0.322, p = 0.028) and L-Arg/ADMA ratio (r = 0.331, p = 0.015), and for the 6-min walk test (6MWT) with ADMA (r= −0.314, p = 0.024) and L-Arg/ADMA ratio (r = 0.346, p = 0.015). No significant differences between UC and ET changes of NO parameters were observed at 3-month follow-up. Higher L-hArg levels were associated with a greater improvement in peak oxygen uptake (peak (Figure presented.) O2) at follow-up: 3.4 ± 2.8 vs. 1.1 ± 2.9 mL/min/kg (p = 0.005). Conclusions: Exercise intervention did not influence NO parameters in HFpEF patients, but L-hArg was related to change in peak (Figure presented.) O2.

Involved external institutions

Georg-August-Universität Göttingen DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK e.V.) DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE)

How to cite

APA:

Baldassarri, F., Schwedhelm, E., Atzler, D., Boeger, R.H., Cordts, K., Haller, B.,... Duvinage, A. (2018). Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction. Biomarkers, 23(6), 540-550. https://doi.org/10.1080/1354750X.2018.1460762

MLA:

Baldassarri, Flavia, et al. "Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction." Biomarkers 23.6 (2018): 540-550.

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