Peeken JC, Goldberg T, Knie C, Komboz B, Bernhofer M, Pasa F, Kessel KA, Tafti PD, Rost B, Nuesslin F, Braun AE, Combs SE (2018)
Publication Type: Journal article
Publication year: 2018
Book Volume: 194
Pages Range: 824-834
Journal Issue: 9
DOI: 10.1007/s00066-018-1294-2
Background and purpose: Current prognostic models for soft tissue sarcoma (STS) patients are solely based on staging information. Treatment-related data have not been included to date. Including such information, however, could help to improve these models. Materials and methods: A single-center retrospective cohort of 136 STS patients treated with radiotherapy (RT) was analyzed for patients’ characteristics, staging information, and treatment-related data. Therapeutic imaging studies and pathology reports of neoadjuvantly treated patients were analyzed for signs of response. Random forest machine learning-based models were used to predict patients’ death and disease progression at 2 years. Pre-treatment and treatment models were compared. Results: The prognostic models achieved high performances. Using treatment features improved the overall performance for all three classification types: prediction of death, and of local and systemic progression (area under the receiver operatoring characteristic curve (AUC) of 0.87, 0.88, and 0.84, respectively). Overall, RT-related features, such as the planning target volume and total dose, had preeminent importance for prognostic performance. Therapy response features were selected for prediction of disease progression. Conclusions: A machine learning-based prognostic model combining known prognostic factors with treatment- and response-related information showed high accuracy for individualized risk assessment. This model could be used for adjustments of follow-up procedures.
APA:
Peeken, J.C., Goldberg, T., Knie, C., Komboz, B., Bernhofer, M., Pasa, F.,... Combs, S.E. (2018). Treatment-related features improve machine learning prediction of prognosis in soft tissue sarcoma patients Therapieinformationen verbessern auf maschinellem Lernen basierende prognostische Einschätzungen für Patienten mit Weichteilsarkomen. Strahlentherapie und Onkologie, 194(9), 824-834. https://doi.org/10.1007/s00066-018-1294-2
MLA:
Peeken, Jan C., et al. "Treatment-related features improve machine learning prediction of prognosis in soft tissue sarcoma patients Therapieinformationen verbessern auf maschinellem Lernen basierende prognostische Einschätzungen für Patienten mit Weichteilsarkomen." Strahlentherapie und Onkologie 194.9 (2018): 824-834.
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