Modeling the variation in speed of sound between couplant and tissue improves the spectral accuracy of multispectral optoacoustic tomography
Yang H, Juestel D, Prakash J, Ntziachristos V (2019)
Publication Type: Conference contribution
Publication year: 2019
Journal
Publisher: SPIE
Book Volume: 10890
Conference Proceedings Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Event location: San Francisco, CA, USA
ISBN: 9781510624221
DOI: 10.1117/12.2506425
Abstract
Even though the speed of sound (SoS) is non-homogeneous in biological tissue, most reconstruction algorithms for optoacoustic imaging neglect its variation. In addition, when heavy water is used as coupling medium to enable imaging of certain biological chromophores such as lipids and proteins, the SoS also differs significantly between couplant and tissue. While the assumption of uniform SoS is known to introduce visible deformations of features in single-wavelength optoacoustic images, the spectral error introduced by the assumption of uniform SoS is not fully understood. In this work, we provide an in-depth spectral analysis of multi-spectral optoacoustic imaging artifacts that result from the assumption of uniform SoS in situations where SoS changes substantially. We propose a dual-SoS model to incorporate the SoS variation between the couplant and the sample. Tissue-mimicking phantom experiments and in vivo measurements show that uniform SoS reconstruction causes spectral smearing, which dual-SoS modeling can largely eliminate. Due to this increased spectral accuracy, the method has the potential to improve clinical studies that rely on quantitative optoacoustic imaging of biomolecules like hemoglobin or lipids.
Involved external institutions
Germany (DE)How to cite
APA:
Yang, H., Juestel, D., Prakash, J., & Ntziachristos, V. (2019). Modeling the variation in speed of sound between couplant and tissue improves the spectral accuracy of multispectral optoacoustic tomography. In Natan T. Shaked, Oliver Hayden (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. San Francisco, CA, USA: SPIE.
MLA:
Yang, Hong, et al. "Modeling the variation in speed of sound between couplant and tissue improves the spectral accuracy of multispectral optoacoustic tomography." Proceedings of the Label-Free Biomedical Imaging and Sensing 2019, LBIS 2019, San Francisco, CA, USA Ed. Natan T. Shaked, Oliver Hayden, SPIE, 2019.
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