In vivo hybrid microscopy of small model organisms
Seeger M, Westmeyer G, Ntziachristos V (2019)
Publication Type: Conference contribution
Publication year: 2019
Publisher: OSA - The Optical Society
Book Volume: Part F142-ECBO 2019
Conference Proceedings Title: Optics InfoBase Conference Papers
Event location: Munich, NLD
ISBN: 9781557528209
DOI: 10.1117/12.2530923
Abstract
We present the investigation of in vivo small model organisms, which are well established in biological and biomedical research, using a hybrid multiphoton and optoacoustic microscope (HyMPOM). The unique capabilities of HyMPOM for multimodal and potentially label-free signal acquisition, high resolution, as well as deep and fast imaging allow extraction of detailed information across large areas of living tissue on the microscale. Applying HyMPOM to living zebrafish-like fish larvae allowed exploration of the structural composition of the entire brain, including the brain vasculature and the neuronal network. Applying HyMPOM to the ears of living mice enabled accurate imaging of vasculature, connective tissue, keratinocytes, and sebaceous glands. The hybrid microscope proposed here constitutes a novel approach to explore small model organisms in vivo in great detail by revealing the spatial distribution and interplay of various tissue compartments on the microscale.
Involved external institutions
Germany (DE)How to cite
APA:
Seeger, M., Westmeyer, G., & Ntziachristos, V. (2019). In vivo hybrid microscopy of small model organisms. In Optics InfoBase Conference Papers. Munich, NLD: OSA - The Optical Society.
MLA:
Seeger, Markus, Gil Westmeyer, and Vasilis Ntziachristos. "In vivo hybrid microscopy of small model organisms." Proceedings of the European Conference on Biomedical Optics, ECBO_2019, Munich, NLD OSA - The Optical Society, 2019.
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