Photocontrollable Proteins for Optoacoustic Imaging
Mishra K, Fuenzalida-Werner JP, Ntziachristos V, Stiel AC (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 91
Pages Range: 5470-5477
Journal Issue: 9
DOI: 10.1021/acs.analchem.9b01048
Abstract
Photocontrollable proteins revolutionized life-science imaging due to their contribution to subdiffraction-resolution optical microscopy. They might have yet another lasting impact on photoor optoacoustic imaging (OA). OA combines optical contrast with ultrasound detection enabling high-resolution real-time in vivo imaging well-beyond the typical penetration depth of optical methods. While OA already showed numerous applications relying on endogenous contrast from blood hemoglobin or lipids, its application in the life-science was limited by a lack of labels overcoming the strong signal from the aforementioned endogenous absorbers. Here, a number of recent studies showed that photocontrollable proteins provide the means to overcome this barrier eventually enabling OA to image small cell numbers in a complete organism in vivo. In this Feature article, we introduce the key photocontrollable proteins, explain the basic concepts, and highlight achievements that have been already made.
Involved external institutions
Germany (DE)How to cite
APA:
Mishra, K., Fuenzalida-Werner, J.P., Ntziachristos, V., & Stiel, A.C. (2019). Photocontrollable Proteins for Optoacoustic Imaging. Analytical Chemistry, 91(9), 5470-5477. https://doi.org/10.1021/acs.analchem.9b01048
MLA:
Mishra, Kanuj, et al. "Photocontrollable Proteins for Optoacoustic Imaging." Analytical Chemistry 91.9 (2019): 5470-5477.
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