Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green
Mokrousov MD, Novoselova M, Nolan J, Harrington W, Rudakovskaya P, Bratashov DN, Galanzha E, Fuenzalida-Werner JP, Yakimov BP, Nazarikov G, Drachev VP, Shirshin EA, Ntziachristos V, Stiel AC, Zharov VP, Gorin DA (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 10
Pages Range: 4775-4789
Journal Issue: 9
Abstract
A new type of bimodal contrast agent was made that is based on the self-quenching of indocyanine green (ICG) encapsulated in a biocompatible and biodegradable polymer shell. The increasing of a local ICG concentration that is necessary for the obtaining of self-quenching effect was achieved by freezing-induced loading and layer-by-layer assembly. As a result, an efficient photoacoustic(optoacoustic)/fluorescent contrast agent based on composite indocyanine green/polymer particles was successfully prepared and was characterized by fluorescence and photoacoustic(optoacoustic) tomography in vitro. This type of contrast agent holds good promise for clinical application owing to its high efficiency and biosafety.
Involved external institutions
Lomonosov Moscow State University / Московский государственный университет имени М.В.Ломоносова
Russian Federation (RU)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
University of Arkansas
United States (USA) (US)
Skolkovo Institute of Science and Technology
Russian Federation (RU)
Saratov Chernyshevsky State University / Saratovskiy Natsional'nyy Issledovatel'skiy Gosudarstvennyy Universitet Imeni N.g. Chernyshevskogo
Russian Federation (RU)
Russian Federation (RU)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
University of Arkansas
United States (USA) (US)
Skolkovo Institute of Science and Technology
Russian Federation (RU)
Saratov Chernyshevsky State University / Saratovskiy Natsional'nyy Issledovatel'skiy Gosudarstvennyy Universitet Imeni N.g. Chernyshevskogo
Russian Federation (RU)
How to cite
APA:
Mokrousov, M.D., Novoselova, M., Nolan, J., Harrington, W., Rudakovskaya, P., Bratashov, D.N.,... Gorin, D.A. (2019). Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green. Biomedical Optics Express, 10(9), 4775-4789. https://doi.org/10.1364/BOE.10.004775
MLA:
Mokrousov, Maksim D., et al. "Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green." Biomedical Optics Express 10.9 (2019): 4775-4789.
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