Biodegradable Fluorescent Nanoparticles for Endoscopic Detection of Colorectal Carcinogenesis

Rogalla S, Flisikowski K, Gorpas D, Mayer AT, Flisikowska T, Mandella MJ, Ma X, Casey KM, Felt SA, Saur D, Ntziachristos V, Schnieke A, Contag CH, Gambhir SS, Harmsen S (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Advanced Functional Materials Wiley-VCH Verlag

Book Volume: 29

Article Number: 1904992

Journal Issue: 51

DOI: 10.1002/adfm.201904992

Abstract

Early and comprehensive endoscopic detection of colonic dysplasia—the most clinically significant precursor lesion to colorectal adenocarcinoma—provides an opportunity for timely, minimally invasive intervention to prevent malignant transformation. Here, the development and evaluation of biodegradable near-infrared fluorescent silica nanoparticles (FSN) that have the potential to improve adenoma detection during fluorescence-assisted white-light colonoscopic surveillance in rodent and human-scale models of colorectal carcinogenesis is described. FSNs are biodegradable (t1/2 of 2.7 weeks), well-tolerated, and enable detection and delineation of adenomas as small as 0.5 mm2 with high tumor-to-background ratios. Furthermore, in the human scale, APC1311/+ porcine model, the clinical feasibility and benefit of using FSN-guided detection of colorectal adenomas using video-rate fluorescence-assisted white-light endoscopy is demonstrated. Since nanoparticles of similar size (e.g., 100–150 nm) or composition (i.e., silica and silica/gold hybrid) have already been successfully translated to the clinic, and clinical fluorescent/white-light endoscopy systems are becoming more readily available, there is a viable path towards clinical translation of the proposed strategy for early colorectal cancer detection and prevention in high-risk patients.

Involved external institutions

Stanford University US United States (USA) (US) Technische Universität München (TUM) DE Germany (DE) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) Deutsches Krebsforschungszentrum (DKFZ) DE Germany (DE) Michigan State University US United States (USA) (US)

How to cite

APA:

Rogalla, S., Flisikowski, K., Gorpas, D., Mayer, A.T., Flisikowska, T., Mandella, M.J.,... Harmsen, S. (2019). Biodegradable Fluorescent Nanoparticles for Endoscopic Detection of Colorectal Carcinogenesis. Advanced Functional Materials, 29(51). https://doi.org/10.1002/adfm.201904992

MLA:

Rogalla, Stephan, et al. "Biodegradable Fluorescent Nanoparticles for Endoscopic Detection of Colorectal Carcinogenesis." Advanced Functional Materials 29.51 (2019).

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