Sales AHA, Bette S, Barz M, Huber T, Wiestler B, Ryang YM, Schmidt-Graf F, Liesche F, Combs SE, Meyer B, Gempt J (2019)
Publication Type: Journal article
Publication year: 2019
Book Volume: 142
Pages Range: 529-536
Journal Issue: 3
DOI: 10.1007/s11060-019-03124-z
Purpose: The aim of this study is to investigate the association between postoperative tumor volume and overall survival (OS) of O 6 -methylguanine DNA methyltransferase (MGMT)-unmethylated glioblastoma patients. Methods: One hundred-twenty-six patients with MGMT-unmethylated glioblastoma who were treated either with surgical resection or needle biopsy between 2006 and 2015 were included in this retrospective cohort. Pre- and postcontrast T1 weighted images were evaluated in order to determine pre- and postoperative contrast-enhancing tumor volumes (CE-TV). Cox regression models adjusted for other significant prognostic factors were used to investigate the association between postoperative tumor volume and survival. Results: Complete resection of CE-TV was significantly associated with longer OS in the univariate analysis (HR 0.61; 95% CI 0.40–0.94; p = 0.02). However, this fact could not be confirmed after adjusting the model for other relevant prognostic factors (HR 1.01; 95% CI 0.65–1.55; p = 0.962). Postoperative CE-TV was significantly associated with survival in both univariate (HR: 1.04; 95% CI 1.025–1.055; p < 0.001) and multivariate analyses (HR: 1.027; 95% CI 1.005–1.049; p = 0.014). Conclusions: Although complete resection of tumor tissue was not significantly associated with longer OS in MGMT-unmethylated GBM patients, maximum safe resection should always be attempted, since postoperative tumor volume is strongly associated with OS.
APA:
Sales, A.H.A., Bette, S., Barz, M., Huber, T., Wiestler, B., Ryang, Y.-M.,... Gempt, J. (2019). Role of postoperative tumor volume in patients with MGMT-unmethylated glioblastoma. Journal of Neuro-Oncology, 142(3), 529-536. https://doi.org/10.1007/s11060-019-03124-z
MLA:
Sales, Arthur H. A., et al. "Role of postoperative tumor volume in patients with MGMT-unmethylated glioblastoma." Journal of Neuro-Oncology 142.3 (2019): 529-536.
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