Peeken JC, Molina-Romero M, Diehl C, Menze BH, Straube C, Meyer B, Zimmer C, Wiestler B, Combs SE (2019)
Publication Type: Journal article
Publication year: 2019
Book Volume: 138
Pages Range: 166-172
DOI: 10.1016/j.radonc.2019.06.031
Purpose: Glioblastoma is routinely treated by concomitant radiochemotherapy. Current target definition guidelines use anatomic MRI (magnetic resonance imaging) scans, taking into account contrast enhancement and the rather unspecific hyperintensity on the fluid-attenuated inversion recovery (FLAIR) sequence. Methods and materials: We applied deep learning based free water correction of diffusion tensor imaging (DTI) scans to estimate the infiltrative gross tumor volume (iGTV) inside of the FLAIR hyperintense region. We analyzed the resulting iGTVs and their impact on target volume definition in a retrospective cohort of 33 GBM patients. Results: iGTVs were significantly smaller compared to standard pre- and post-operative gross tumor volume (GTV) definitions. Two novel infiltrative tumor GTVs (nGTV
APA:
Peeken, J.C., Molina-Romero, M., Diehl, C., Menze, B.H., Straube, C., Meyer, B.,... Combs, S.E. (2019). Deep learning derived tumor infiltration maps for personalized target definition in Glioblastoma radiotherapy. Radiotherapy and Oncology, 138, 166-172. https://doi.org/10.1016/j.radonc.2019.06.031
MLA:
Peeken, Jan C., et al. "Deep learning derived tumor infiltration maps for personalized target definition in Glioblastoma radiotherapy." Radiotherapy and Oncology 138 (2019): 166-172.
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