Sungnak W, Huang N, Becavin C, Berg M, Queen R, Litvinukova M, Talavera-Lopez C, Maatz H, Reichart D, Sampaziotis F, Worlock KB, Yoshida M, Barnes JL (2020)
Publication Type: Journal article
Publication year: 2020
Book Volume: 26
Pages Range: 681-687
Journal Issue: 5
DOI: 10.1038/s41591-020-0868-6
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
APA:
Sungnak, W., Huang, N., Becavin, C., Berg, M., Queen, R., Litvinukova, M.,... Barnes, J.L. (2020). SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nature Medicine, 26(5), 681-687. https://doi.org/10.1038/s41591-020-0868-6
MLA:
Sungnak, Waradon, et al. "SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes." Nature Medicine 26.5 (2020): 681-687.
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