Franklin JM, Irving B, Papiez BW, Kallehauge JF, Wang LM, Goldin RD, Harris AL, Anderson EM, Schnabel JA, Chappell MA, Brady M, Sharma RA, Gleeson F (2020)
Publication Type: Journal article
Publication year: 2020
Book Volume: 126
Article Number: 108934
DOI: 10.1016/j.ejrad.2020.108934
Purpose: To use a novel segmentation methodology based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to define tumour subregions of liver metastases from colorectal cancer (CRC), to compare these with histology, and to use these to compare extracted pharmacokinetic (PK) parameters between tumour subregions. Materials and Methods: This ethically-approved prospective study recruited patients with CRC and ≥1 hepatic metastases scheduled for hepatic resection. Patients underwent DCE-MRI pre-metastasectomy. Histological sections of resection specimens were spatially matched to DCE-MRI acquisitions and used to define histological subregions of viable and non-viable tumour. A semi-automated voxel-wise image segmentation algorithm based on the DCE-MRI contrast-uptake curves was used to define imaging subregions of viable and non-viable tumour. Overlap of histologically-defined and imaging subregions was compared using the Dice similarity coefficient (DSC). DCE-MRI PK parameters were compared for the whole tumour and histology-defined and imaging-derived subregions. Results: Fourteen patients were included in the analysis. Direct histological comparison with imaging was possible in nine patients. Mean DSC for viable tumour subregions defined by imaging and histology was 0.738 (range 0.540-0.930). There were significant differences between Ktrans and k
APA:
Franklin, J.M., Irving, B., Papiez, B.W., Kallehauge, J.F., Wang, L.M., Goldin, R.D.,... Gleeson, F. (2020). Tumour subregion analysis of colorectal liver metastases using semi-automated clustering based on DCE-MRI: Comparison with histological subregions and impact on pharmacokinetic parameter analysis. European Journal of Radiology, 126. https://doi.org/10.1016/j.ejrad.2020.108934
MLA:
Franklin, James M., et al. "Tumour subregion analysis of colorectal liver metastases using semi-automated clustering based on DCE-MRI: Comparison with histological subregions and impact on pharmacokinetic parameter analysis." European Journal of Radiology 126 (2020).
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