Sensitivity enhanced photoacoustic imaging using a high-frequency PZT transducer with an integrated front-end amplifier
Yang C, Jian X, Zhu X, Lv J, Jiao Y, Han Z, Stylogiannis A, Ntziachristos V, Sergiadis G, Cui Y (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 20
Article Number: 766
Journal Issue: 3
DOI: 10.3390/s20030766
Abstract
Photoacoustic (PA) imaging is a hybrid imaging technique that can provide both structural and functional information of biological tissues. Due to limited permissible laser energy deposited on tissues, highly sensitive PA imaging is required. Here, we developed a 20 MHz lead zirconium titanate (PZT) transducer (1.5 mm × 3 mm) with front-end amplifier circuits for local signal processing to achieve sensitivity enhanced PA imaging. The electrical and acoustic performance was characterized. Experiments on phantoms and chicken breast tissue were conducted to validate the imaging performance. The fabricated prototype shows a bandwidth of 63% and achieves a noise equivalent pressure (NEP) of 0.24 mPa/√Hz and a receiving sensitivity of 62.1 μV/Pa at 20 MHz without degradation of the bandwidth. PA imaging of wire phantoms demonstrates that the prototype is capable of improving the detection sensitivity by 10 dB compared with the traditional transducer without integrated amplifier. In addition, in vitro experiments on chicken breast tissue show that structures could be imaged with enhanced contrast using the prototype and the imaging depth range was improved by 1 mm. These results demonstrate that the transducer with an integrated front-end amplifier enables highly sensitive PA imaging with improved penetration depth. The proposed method holds the potential for visualization of deep tissue structures and enhanced detection of weak physiological changes.
Involved external institutions
University of Science and Technology of China (USTC)
China (CN)
Chinese Academy of Sciences (CAS) / 中国科学院
China (CN)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
China (CN)
Chinese Academy of Sciences (CAS) / 中国科学院
China (CN)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
How to cite
APA:
Yang, C., Jian, X., Zhu, X., Lv, J., Jiao, Y., Han, Z.,... Cui, Y. (2020). Sensitivity enhanced photoacoustic imaging using a high-frequency PZT transducer with an integrated front-end amplifier. Sensors, 20(3). https://doi.org/10.3390/s20030766
MLA:
Yang, Chen, et al. "Sensitivity enhanced photoacoustic imaging using a high-frequency PZT transducer with an integrated front-end amplifier." Sensors 20.3 (2020).
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