Ovsepian SV, Jiang Y, Sardella TCP, Malekzadeh-Najafabadi J, Burton NC, Yu X, Ntziachristos V (2020)
Publication Type: Journal article
Publication year: 2020
Book Volume: 17
Article Number: 100153
DOI: 10.1016/j.pacs.2019.100153
To date, the vast majority of intra-vital neuroimaging systems applied in clinic and diagnostics is stationary with a rigid scanning element, requires specialized facilities and costly infrastructure. Here, we describe a simple yet radical approach for optoacoustic (photoacoustic) brain imaging in vivo using a light-weight handheld probe. It enables multispectral video-rate visualization of hemoglobin gradient changes in the cortex of adult rats induced by whisker and forelimb sensory inputs, as well as by optogenetic stimulation of intra-cortical connections. With superb penetration and molecular specificity, described here in method holds major promises for future applications in research, routine ambulatory neuroimaging, and diagnostics.
APA:
Ovsepian, S.V., Jiang, Y., Sardella, T.C.P., Malekzadeh-Najafabadi, J., Burton, N.C., Yu, X., & Ntziachristos, V. (2020). Visualizing cortical response to optogenetic stimulation and sensory inputs using multispectral handheld optoacoustic imaging. Photoacoustics, 17. https://dx.doi.org/10.1016/j.pacs.2019.100153
MLA:
Ovsepian, Saak V., et al. "Visualizing cortical response to optogenetic stimulation and sensory inputs using multispectral handheld optoacoustic imaging." Photoacoustics 17 (2020).
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