Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging
Yang H, Juestel D, Prakash J, Karlas A, Helfen A, Masthoff M, Wildgruber M, Ntziachristos V (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 19
Article Number: 100172
DOI: 10.1016/j.pacs.2020.100172
Abstract
Using the same ultrasound detector, hybrid optoacoustic-ultrasound (OPUS) imaging provides concurrent scans of tissue slices or volumes and visualizes complementary sound- and light-based contrast at similar resolutions. In addition to the benefit of hybrid contrast, spatial co-registration enables images from one modality to be employed as prior information for improving an aspect of the performance of the other modality. We consider herein a handheld OPUS system and utilize structural information from ultrasound images to guide regional Laplacian regularization-based reconstruction of optoacoustic images. Using phantoms and data from OPUS scans of human radial and carotid arteries, we show that ultrasound-driven optoacoustic inversion reduces limited-view artefacts and improves image contrast. In phantoms, prior-integrated reconstruction leads to a 50 % higher contrast-to-noise ratio (CNR) of the image than standard reconstruction, and a 17 % higher structural similarity (SSIM) index. In clinical data, prior-integrated reconstruction detects deep-seated radial arteries with higher CNR than the standard method at three different depths. In this way, the prior-integrated method offers unique insights into atherosclerotic carotid plaques in humans (with p<0.01 between patients and healthy volunteers), potentially paving the way for new abilities in vascular imaging and more generally in optoacoustic imaging.
Involved external institutions
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
Indian Institute of Science (IISc)
India (IN)
Universitätsklinikum Münster
Germany (DE)
Germany (DE)
Indian Institute of Science (IISc)
India (IN)
Universitätsklinikum Münster
Germany (DE)
How to cite
APA:
Yang, H., Juestel, D., Prakash, J., Karlas, A., Helfen, A., Masthoff, M.,... Ntziachristos, V. (2020). Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging. Photoacoustics, 19. https://doi.org/10.1016/j.pacs.2020.100172
MLA:
Yang, Hong, et al. "Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging." Photoacoustics 19 (2020).
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