Extending the Hybrid Surgical Guidance Concept with Freehand Fluorescence Tomography

Van Oosterom MN, Meershoek P, Welling MM, Pinto F, Matthies P, Simon H, Wendler T, Navab N, Van De Velde CJH, Van Der Poel HG, Van Leeuwen FWB (2020)

Publication Type: Journal article

Publication year: 2020

Journal

IEEE Transactions on Medical Imaging Institute of Electrical and Electronics Engineers (IEEE)

Book Volume: 39

Pages Range: 226-235

Article Number: 8743423

Journal Issue: 1

DOI: 10.1109/TMI.2019.2924254

Abstract

Within image-guided surgery, 'hybrid' guidance technologies have been used to integrate the complementary features of radioactive guidance and fluorescence guidance. Here, we explore how the generation of a novel freehand fluorescence (fhFluo) imaging approach complements freehand SPECT (fhSPECT) in a hybrid setup. Near-infrared optical tracking was used to register the position and the orientation of a hybrid opto-nuclear detection probe while recording its readings. Dedicated look-up table models were used for 3D reconstruction. In phantom and excised tissue settings (i.e., flat-surface human skin explants), fhSPECT and fhFluo were investigated for image resolution and in-tissue signal penetration. Finally, the combined potential of these freehand technologies was evaluated on prostate and lymph node specimens of prostate cancer patients receiving prostatectomy and sentinel lymph node dissection (tracers: indocyanine green (ICG) +99m Tc-nanocolloid or ICG-99mTc-nanocolloid). After hardware and software integration, the hybrid setup created 3D nuclear and fluorescence tomography scans. The imaging resolution of fhFluo (1 mm) was superior to that of fhSPECT (6 mm). Fluorescence modalities were confined to a maximum depth of 0.5 cm, while nuclear modalities were usable at all evaluated depths (<2 cm). Both fhSPECT and fhFluo enabled augmented-and virtual-reality navigation toward segmented image hotspots, including relative hotspot quantification with an accuracy of 3.9% and 4.1%. Imaging in surgical specimens confirmed these trends (fhSPECT: in-depth detectability, low resolution, and fhFluo: superior resolution, superficial detectability). Overall, when radioactive and fluorescent tracer signatures are used, fhFluo has complementary value to fhSPECT. Combined the freehand technologies render a unique hybrid imaging and navigation modality.

Involved external institutions

Leiden University NL Netherlands (NL) Health Data Pioneers GmbH DE Germany (DE) Eurorad FR France (FR) Technische Universität München (TUM) DE Germany (DE) Antoni van Leeuwenhoek NL Netherlands (NL)

How to cite

APA:

Van Oosterom, M.N., Meershoek, P., Welling, M.M., Pinto, F., Matthies, P., Simon, H.,... Van Leeuwen, F.W.B. (2020). Extending the Hybrid Surgical Guidance Concept with Freehand Fluorescence Tomography. IEEE Transactions on Medical Imaging, 39(1), 226-235. https://doi.org/10.1109/TMI.2019.2924254

MLA:

Van Oosterom, Matthias N., et al. "Extending the Hybrid Surgical Guidance Concept with Freehand Fluorescence Tomography." IEEE Transactions on Medical Imaging 39.1 (2020): 226-235.

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