Neurocognitive functioning and health-related quality of life in adult medulloblastoma patients: long-term outcomes of the NOA-07 study

Dirven L, Luerding R, Beier D, Bumes E, Reinert C, Seidel C, Bonsanto MM, Bremer M, Rieken S, Combs SE, Herrlinger U, Seliger C, Kuntze H, Mayer-Steinacker R, Dieing A, Bartels C, Schnell O, Weyerbrock A, Seidel S, Grauer O, Nadji-Ohl M, Paulsen F, Weller M, Wick W, Hau P (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Book Volume: 148

Pages Range: 117-130

Journal Issue: 1

DOI: 10.1007/s11060-020-03502-y

Abstract

Background: Combined radiochemotherapy followed by maintenance chemotherapy with cisplatin, lomustine and vincristine within the NOA-07 study resulted in considerable short-term toxicity in adult medulloblastoma patients. Here we investigated the long-term impact of this treatment, focusing on neurocognitive functioning and health-related quality of life (HRQoL). Methods: Neurocognitive functioning and HRQoL scores over time were determined, and differences between the post-treatment and follow-up assessments were calculated up to 18 months for neurocognition and 60 months for HRQoL. Results: 28/30 patients were analyzed. The three preselected HRQoL scales (role, social and cognitive functioning) showed improved scores, to a clinically relevant extent (≥ 10 points), compared to post-treatment levels up to 30 months, but decreased afterwards. Z-scores for verbal working memory were worse during follow-up compared to post-treatment scores and remained impaired during 18 months follow-up (i.e. z-score below − 1 standard deviation). Attention was impaired post-treatment, and remained impaired to a clinically relevant extent during follow-up. Coordination/processing speed and lexical verbal fluency improved compared to post-treatment scores, and remained within the normal range thereafter. Other tests of verbal fluency were stable over time, with z-scores within the normal range. Conclusions: This long-term follow-up study showed that the NOA-07 treatment regimen was not associated with a deterioration in HRQoL in the post-treatment period. Verbal working memory deteriorated, while other neurocognitive domains did not seem to be impacted negatively by the treatment.

Authors with CRIS profile

Involved external institutions

Leiden University Netherlands (NL) Universität Regensburg Germany (DE) University of Southern Denmark / Syddansk Universitet Denmark (DK) Universitätsklinikum Heidelberg Germany (DE) Universitätsklinikum Leipzig Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Universitätsklinikum Göttingen Germany (DE) Technische Universität München (TUM) Germany (DE) Rheinische Friedrich-Wilhelms-Universität Bonn Germany (DE) Universitätsmedizin der Johannes Gutenberg-Universität Mainz Germany (DE) Universitätsklinikum Ulm Germany (DE) Vivantes - Netzwerk für Gesundheit GmbH Germany (DE) Universitätsklinikum Magdeburg A.ö.R. Germany (DE) Universitätsklinikum Freiburg Germany (DE) Ruhr-Universität Bochum (RUB) Germany (DE) Universitätsklinikum Münster Germany (DE) Klinikum Stuttgart Germany (DE) Universitätsklinikum Tübingen Germany (DE)

How to cite

APA:

Dirven, L., Luerding, R., Beier, D., Bumes, E., Reinert, C., Seidel, C.,... Hau, P. (2020). Neurocognitive functioning and health-related quality of life in adult medulloblastoma patients: long-term outcomes of the NOA-07 study. Journal of Neuro-Oncology, 148(1), 117-130. https://doi.org/10.1007/s11060-020-03502-y

MLA:

Dirven, Linda, et al. "Neurocognitive functioning and health-related quality of life in adult medulloblastoma patients: long-term outcomes of the NOA-07 study." Journal of Neuro-Oncology 148.1 (2020): 117-130.

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