RNA velocity—current challenges and future perspectives

Bergen V, Soldatov RA, Kharchenko P, Theis FJ (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Molecular Systems Biology Nature Publishing Group: Open Access Journals - Option B / European Molecular Biology Organization

Book Volume: 17

Article Number: e10282

Journal Issue: 8

DOI: 10.15252/msb.202110282

Abstract

RNA velocity has enabled the recovery of directed dynamic information from single-cell transcriptomics by connecting measurements to the underlying kinetics of gene expression. This approach has opened up new ways of studying cellular dynamics. Here, we review the current state of RNA velocity modeling approaches, discuss various examples illustrating limitations and potential pitfalls, and provide guidance on how the ensuing challenges may be addressed. We then outline future directions on how to generalize the concept of RNA velocity to a wider variety of biological systems and modalities.

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich

Germany (DE) Harvard University

United States (USA) (US)

How to cite

APA:

Bergen, V., Soldatov, R.A., Kharchenko, P., & Theis, F.J. (2021). RNA velocity—current challenges and future perspectives. Molecular Systems Biology, 17(8). https://doi.org/10.15252/msb.202110282

MLA:

Bergen, Volker, et al. "RNA velocity—current challenges and future perspectives." Molecular Systems Biology 17.8 (2021).

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