Bioengineered bacterial vesicles for optoacoustics-guided phototherapy
Gujrati V, Ntziachristos V (2021)
Publication Type: Book chapter / Article in edited volumes
Publication year: 2021
Journal
Publisher: Academic Press Inc.
Series: Methods in Enzymology
Book Volume: 657
Pages Range: 349-364
DOI: 10.1016/bs.mie.2021.06.030
Abstract
Genetically engineered bacterial outer membrane vesicles (OMVs) offer promising applications for gene therapy, immunotherapy, and vaccine delivery. Importantly, OMVs are biocompatible, biodegradable, and easy to engineer and produce on a large scale. In this chapter, we discuss the development and application of bioengineered OMVs for optoacoustics-guided phototherapy applications (theranostics). We provide detailed protocols for OMVs preparation, characterization, and in vitro and in vivo validation. The engineered OMVs carry the biopolymer melanin, which generates a strong optoacoustic (OA) signal and intense heat upon absorption of near-infrared (NIR) light, enabling optoacoustics-guided cancer diagnosis and photothermal therapy in vivo.
Involved external institutions
Germany (DE)How to cite
APA:
Gujrati, V., & Ntziachristos, V. (2021). Bioengineered bacterial vesicles for optoacoustics-guided phototherapy. In Jefferson Chan (Eds.), (pp. 349-364). Academic Press Inc..
MLA:
Gujrati, Vipul, and Vasilis Ntziachristos. "Bioengineered bacterial vesicles for optoacoustics-guided phototherapy." Ed. Jefferson Chan, Academic Press Inc., 2021. 349-364.
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