Chemotherapeutic effects on breast tumor hemodynamics revealed by eigenspectra multispectral optoacoustic tomography (emsot)
Liapis E, Karlas A, Klemm U, Ntziachristos V (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 11
Pages Range: 7813-7828
Journal Issue: 16
DOI: 10.7150/THNO.56173
Abstract
Non-invasive monitoring of hemodynamic tumor responses to chemotherapy could provide unique insights into the development of therapeutic resistance and inform therapeutic decision-making in the clinic. Methods: Here, we examined the longitudinal and dynamic effects of the common chemotherapeutic drug Taxotere on breast tumor (KPL-4) blood volume and oxygen saturation using eigenspectra multispectral optoacoustic tomography (eMSOT) imaging over a period of 41 days. Tumor vascular function was assessed by dynamic oxygen-enhanced eMSOT (OE-eMSOT). The obtained in vivo optoacoustic data were thoroughly validated by ex vivo cryoimaging and immunohistochemical staining against markers of vascularity and hypoxia. Results: We provide the first preclinical evidence that prolonged treatment with Taxotere causes a significant drop in mean whole tumor oxygenation. Furthermore, application of OE-eMSOT showed a diminished vascular response in Taxotere-treated tumors and revealed the presence of static blood pools, indicating increased vascular permeability. Conclusion: Our work has important translational implications and supports the feasibility of eMSOT imaging for non-invasive assessment of tumor microenvironmental responses to chemotherapy.
Involved external institutions
Germany (DE)How to cite
APA:
Liapis, E., Karlas, A., Klemm, U., & Ntziachristos, V. (2021). Chemotherapeutic effects on breast tumor hemodynamics revealed by eigenspectra multispectral optoacoustic tomography (emsot). Theranostics, 11(16), 7813-7828. https://dx.doi.org/10.7150/THNO.56173
MLA:
Liapis, Evangelos, et al. "Chemotherapeutic effects on breast tumor hemodynamics revealed by eigenspectra multispectral optoacoustic tomography (emsot)." Theranostics 11.16 (2021): 7813-7828.
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