Changes of Right Ventricular Function After Transcatheter Aortic Valve Replacement and Association With Outcomes
Poch F, Thalmann R, Olbrich I, Fellner C, Stundl A, Barthel P, Bradaric C, Laugwitz KL, Kupatt C, Ledwoch J (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 27
Pages Range: 1337-1344
Journal Issue: 12
DOI: 10.1016/j.cardfail.2021.03.007
Abstract
Background: Baseline right ventricular (RV) dysfunction represents a predictor for poor outcome in patients undergoing transcatheter aortic valve replacement (TAVR). However, RV function may improve after TAVR, which could have important implications on outcomes. The aim of the present study was to assess changes in RV function after TAVR and its prognostic value regarding clinical outcome. Methods and Results: Patients undergoing TAVR at our institution were consecutively enrolled and categorized into 4 groups according to changes in RV function during echocardiographic follow-up at 6 months. A total of 188 patients were included. Of those showing normal function at baseline, 87% (130/149) had preserved RV function at follow-up (group 1), whereas 13% (19/149) developed new RV dysfunction (group 2). Of those with RV dysfunction at baseline (39 patients), RV function normalized in 46% (18/39) (group 3) and remained impaired in 54% (21/39) (group 4). The Kaplan–Meier estimated survival at 3 years was highest in patients in group 1 (83%), intermediate in group 2 (65%) and 3 (69%), whereas group 4 had the worst survival (37%; P < .001). Furthermore, new or persistent RV dysfunction was identified to be independently associated with mortality during follow-up (hazard ratio 2.55; interquartile range 1.03–6.47, P = .004). Conclusions: Patients with preserved RV function have a high 3-year survival. Normalization of RV function showed improved survival compared with patients with persistent RV dysfunction, who had a dismal prognosis despite TAVR.
Involved external institutions
Germany (DE)How to cite
APA:
Poch, F., Thalmann, R., Olbrich, I., Fellner, C., Stundl, A., Barthel, P.,... Ledwoch, J. (2021). Changes of Right Ventricular Function After Transcatheter Aortic Valve Replacement and Association With Outcomes. Journal of Cardiac Failure, 27(12), 1337-1344. https://doi.org/10.1016/j.cardfail.2021.03.007
MLA:
Poch, Felix, et al. "Changes of Right Ventricular Function After Transcatheter Aortic Valve Replacement and Association With Outcomes." Journal of Cardiac Failure 27.12 (2021): 1337-1344.
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