The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 – Results from a prospective cohort of outpatient COVID-19 cases
Puchinger K, Castelletti N, Rubio-Acero R, Geldmacher C, Eser TM, Deak F, Paunovic I, Bakuli A, Saathoff E, Von Meyer A, Markgraf A, Falk P, Reich J, Riess F, Girl P, Mueller K, Radon K, Noller JMG, Woelfel R, Hoelscher M, Kroidl I, Wieser A, Olbrich L (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 569
Pages Range: 37-43
DOI: 10.1016/j.virol.2022.02.002
Abstract
Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding of acute and long-term virological and immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May and December 2020 in Munich, Germany, and followed up at multiple defined timepoints for up to one year. RT-PCR and viral culture were performed and seroresponses measured. Participants were classified applying the WHO clinical progression scale. Short symptom to test time (median 5.0 days; p = 0.0016) and high viral loads (VL; median maximum VL: 3∙108 copies/mL; p = 0.0015) were indicative for viral culture positivity. Participants with WHO grade 3 at baseline had significantly higher VLs compared to those with WHO 1 and 2 (p = 0.01). VLs dropped fast within 1 week of symptom onset. Maximum VLs were positively correlated with the magnitude of Ro-N-Ig seroresponse (p = 0.022). Our results describe the dynamics of VLs and antibodies to SARS-CoV-2 in mild to moderate cases that can support public health measures during the ongoing global pandemic.
Involved external institutions
Ludwig-Maximilians-Universität (LMU)
Germany (DE)
Städtisches Klinikum München
Germany (DE)
Deutsches Zentrum für Infektionsforschung (DZIF)
Germany (DE)
Klinikum der Universität München (Großhadern und Innenstadt)
Germany (DE)
Germany (DE)
Städtisches Klinikum München
Germany (DE)
Deutsches Zentrum für Infektionsforschung (DZIF)
Germany (DE)
Klinikum der Universität München (Großhadern und Innenstadt)
Germany (DE)
How to cite
APA:
Puchinger, K., Castelletti, N., Rubio-Acero, R., Geldmacher, C., Eser, T.M., Deak, F.,... Olbrich, L. (2022). The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 – Results from a prospective cohort of outpatient COVID-19 cases. Virology, 569, 37-43. https://doi.org/10.1016/j.virol.2022.02.002
MLA:
Puchinger, Kerstin, et al. "The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 – Results from a prospective cohort of outpatient COVID-19 cases." Virology 569 (2022): 37-43.
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