The sound of drug delivery: Optoacoustic imaging in pharmacology
Liu N, Mishra K, Stiel AC, Gujrati V, Ntziachristos V (2022)
Publication Type: Journal article, Review article
Publication year: 2022
Journal
Book Volume: 189
Article Number: 114506
DOI: 10.1016/j.addr.2022.114506
Abstract
Optoacoustic (photoacoustic) imaging offers unique opportunities for visualizing biological function in vivo by achieving high-resolution images of optical contrast much deeper than any other optical technique. The method detects ultrasound waves that are generated inside tissue by thermo-elastic expansion, i.e., the conversion of light absorption by tissue structures to ultrasound when the tissue is illuminated by the light of varying intensity. Listening instead of looking to light offers the major advantage of image formation with a resolution that obeys ultrasonic diffraction and not photon diffusion laws. While the technique has been widely used to explore contrast from endogenous photo-absorbing molecules, such as hemoglobin or melanin, the use of exogenous agents can extend applications to a larger range of biological and possible clinical applications, such as image-guided surgery, disease monitoring, and the evaluation of drug delivery, biodistribution, and kinetics. This review summarizes recent developments in optoacoustic agents, and highlights new functions visualized and potent pharmacology applications enabled with the use of external contrast agents.
Involved external institutions
Technische Universität München (TUM)
Germany (DE)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
Germany (DE)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
How to cite
APA:
Liu, N., Mishra, K., Stiel, A.C., Gujrati, V., & Ntziachristos, V. (2022). The sound of drug delivery: Optoacoustic imaging in pharmacology. Advanced Drug Delivery Reviews, 189. https://doi.org/10.1016/j.addr.2022.114506
MLA:
Liu, Nian, et al. "The sound of drug delivery: Optoacoustic imaging in pharmacology." Advanced Drug Delivery Reviews 189 (2022).
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