Stereotactic radiosurgery and radiotherapy for resected brain metastases: current pattern of care in the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Association for Radiation Oncology (DEGRO)

Rogers S, Baumert BG, Blanck O, Boehmer D, Bostroem J, Engenhart-Cabillic R, Ermis E, Exner S, Guckenberger M, Habermehl D, Hemmatazad H, Henke G, Lohaus F, Lux S, Mai S, Minasch D, Rezazadeh A, Steffal C, Temming S, Wittig A, Zweifel C, Riesterer O, Combs S (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Book Volume: 198

Pages Range: 919-925

Journal Issue: 10

DOI: 10.1007/s00066-022-01991-6

Abstract

Purpose: Preoperative stereotactic radiosurgery (SRS) of brain metastases may achieve similar local control and better leptomeningeal control rates than postoperative fractionated stereotactic radiotherapy (FSRT) in patients treated with elective metastasectomy. To plan a multicentre trial of preoperative SRS compared with postoperative FSRT, a survey of experts was conducted to determine current practice. Methods: A survey with 15 questions was distributed to the DEGRO Radiosurgery and Stereotactic Radiotherapy Working Group. Participants were asked under what circumstances they offered SRS, FSRT, partial and/or whole brain radiotherapy before or after resection of a brain metastasis, as well as the feasibility of preoperative stereotactic radiosurgery and neurosurgical resection within 6 days. Results: Of 25 participants from 24 centres, 22 completed 100% of the questions. 24 respondents were radiation oncologists and 1 was a neurosurgeon. All 24 centres have one or more dedicated radiosurgery platform and all offer postoperative FSRT. Preoperative SRS is offered by 4/24 (16.7%) centres, and 9/24 (37.5%) sometimes recommend single-fraction postoperative SRS. Partial brain irradiation is offered by 8/24 (33.3%) centres and 12/24 (50%) occasionally recommend whole-brain irradiation. Two centres are participating in clinical trials of preoperative SRS. SRS techniques and fractionation varied between centres. Conclusion: All responding centres currently offer postoperative FSRT after brain metastasectomy. Approximately one third offer single-fraction postoperative SRS and four already perform preoperative SRS. With regard to potential co-investigators, 18 were identified for the PREOP‑2 multicentre trial, which will randomise between preoperative SRS and postoperative FSRT.

Involved external institutions

Kantonsspital Aarau AG Switzerland (CH) Kantonsspital Graubünden Switzerland (CH) Universitätsklinikum Schleswig-Holstein (UKSH) Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Universitätsklinikum Gießen und Marburg (UKGM) Germany (DE) Inselspital, Universitätsspital Bern Switzerland (CH) Strahlenzentrum Hamburg MVZ Germany (DE) Universitätsspital Zürich (USZ) Switzerland (CH) Kantonsspital St.Gallen Switzerland (CH) Universitätsklinikum Carl Gustav Carus Dresden Germany (DE) radprax Holding GmbH und Co. KG Germany (DE) Universitätsklinikum Mannheim Germany (DE) Medizinische Universität Innsbruck Austria (AT) Universitätsklinikum Köln Germany (DE) Sozialmedizinisches Zentrum Süd - Kaiser-Franz-Josef-Spital und Gottfried von Preyer'schem Kinderspital und Geriatriezentrum Favoriten Austria (AT) MEDICLIN Robert Janker Klinik Germany (DE) Universitätsklinikum Jena Germany (DE) Technische Universität München (TUM) Germany (DE)

How to cite

APA:

Rogers, S., Baumert, B.G., Blanck, O., Boehmer, D., Bostroem, J., Engenhart-Cabillic, R.,... Combs, S. (2022). Stereotactic radiosurgery and radiotherapy for resected brain metastases: current pattern of care in the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Association for Radiation Oncology (DEGRO). Strahlentherapie und Onkologie, 198(10), 919-925. https://doi.org/10.1007/s00066-022-01991-6

MLA:

Rogers, S., et al. "Stereotactic radiosurgery and radiotherapy for resected brain metastases: current pattern of care in the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Association for Radiation Oncology (DEGRO)." Strahlentherapie und Onkologie 198.10 (2022): 919-925.

BibTeX: Download