Does renal artery supply indicate treatment success of renal denervation?

Schmid A, Ditting T, Sobotka PA, Veelken R, Schmieder R, Uder M, Ott C (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Cardiovascular and Interventional Radiology Springer Verlag (Germany)

Book Volume: 36

Pages Range: 987-991

Journal Issue: 4

DOI: 10.1007/s00270-013-0652-9

Abstract

Purpose: Renal denervation (RDN) emerged as an innovative interventional antihypertensive therapy. With the exception of pretreatment blood pressure (BP) level, no other clear predictor for treatment efficacy is yet known. We analyzed whether the presence of multiple renal arteries has an impact on BP reduction after RDN. Methods: Fifty-three patients with treatment-resistant hypertension (office BP ≥ 140/90 mmHg and 24-h ambulatory BP monitoring (≥130/80 mmHg) underwent bilateral catheter-based RDN. Patients were stratified into one-vessel (OV) (both sides) and at least multivessel (MV) supply at one side. Both groups were treated on one vessel at each side; in case of multiple arteries, only the dominant artery was treated on each side. Results: Baseline clinical characteristics (including BP, age, and estimated glomerular filtration rate) did not differ between patients with OV (n = 32) and MV (n = 21). Office BP was significantly reduced in both groups at 3 months (systolic: OV -15 ± 23 vs. MV -16 ± 20 mmHg; diastolic: OV -10 ± 12 vs. MV -8 ± 11 mmHg, both p = NS) as well as 6 months (systolic: OV -18 ± 18 vs. MV -17 ± 22 mmHg; diastolic: OV -10 ± 10 vs. -10 ± 12 mmHg, both p = NS) after RDN. There was no difference in responder rate (rate of patients with office systolic BP reduction of at least 10 mmHg after 6 months) between the groups. Conclusion: In patients with multiple renal arteries, RDN of one renal artery - namely, the dominant one - is sufficient to induce BP reduction in treatment-resistant hypertension. © 2013 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).

Authors with CRIS profile

Axel Schmid Institute of Radiology Tilmann Ditting Medizinische Fakultät Roland Veelken Medizinische Fakultät Roland Schmieder Professur für Innere Medizin (Nephrologie) Michael Uder Lehrstuhl für Diagnostische Radiologie Christian Ott Department of Medicine 4 – Nephrology and Hypertension

Involved external institutions

Ohio State University US United States (USA) (US)

How to cite

APA:

Schmid, A., Ditting, T., Sobotka, P.A., Veelken, R., Schmieder, R., Uder, M., & Ott, C. (2013). Does renal artery supply indicate treatment success of renal denervation? Cardiovascular and Interventional Radiology, 36(4), 987-991. https://doi.org/10.1007/s00270-013-0652-9

MLA:

Schmid, Axel, et al. "Does renal artery supply indicate treatment success of renal denervation?" Cardiovascular and Interventional Radiology 36.4 (2013): 987-991.

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